5FCI
| Structure of the vacant uL3 W255C mutant 80S yeast ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. | Deposit date: | 2015-12-15 | Release date: | 2016-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
|
|
6GV1
| Crystal structure of E.coli Multidrug/H+ antiporter MdfA in outward open conformation with bound Fab fragment | Descriptor: | Fab fragment YN1074 heavy chain, Fab fragment YN1074 light chain, Major Facilitator Superfamily multidrug/H+ antiporter MdfA from E.coli, ... | Authors: | Nagarathinam, K, Parthier, C, Stubbs, M.T, Tanabe, M. | Deposit date: | 2018-06-20 | Release date: | 2018-10-03 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism. Nat Commun, 9, 2018
|
|
6ZBV
| Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7 | Descriptor: | Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone | Authors: | Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M.A, Schneider, T.R, Dawson, R.J.P, Nissen, P. | Deposit date: | 2020-06-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural insights into the inhibition of glycine reuptake. Nature, 591, 2021
|
|
6MTE
| Rabbit 80S ribosome with eEF2 and SERBP1 (rotated state) | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Brown, A, Baird, M.R, Yip, M.C.J, Murray, J, Shao, S. | Deposit date: | 2018-10-19 | Release date: | 2018-11-21 | Last modified: | 2019-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of translationally inactive mammalian ribosomes. Elife, 7, 2018
|
|
6OLG
| |
6RM3
| Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome | Descriptor: | 16S rRNA, 23S rRNA, 5S rRNA, ... | Authors: | Barandun, J, Hunziker, M, Vossbrinck, C.R, Klinge, S. | Deposit date: | 2019-05-05 | Release date: | 2019-07-10 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome. Nat Microbiol, 4, 2019
|
|
7FBS
| structure of a channel | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jiang, D.J, Catterall, W.A. | Deposit date: | 2021-07-12 | Release date: | 2021-09-22 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Open-state structure and pore gating mechanism of the cardiac sodium channel. Cell, 184, 2021
|
|
6RME
| Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N | Descriptor: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-06 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
|
|
4D1A
| STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH INDOLYLMETHYL-HYDANTOIN | Descriptor: | (5S)-5-(1H-indol-3-ylmethyl)imidazolidine-2,4-dione, HYDANTOIN TRANSPORT PROTEIN, SODIUM ION | Authors: | Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D. | Deposit date: | 2014-05-01 | Release date: | 2014-07-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1. Embo J., 33, 2014
|
|
7WTN
| Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Tsr1-1 (with Rps2) | Descriptor: | 18S rRNA, 18S rRNA (guanine(1575)-N(7))-methyltransferase, 40S ribosomal protein S1-A, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
|
|
7MJ1
| LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with NAD | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P. | Deposit date: | 2021-04-19 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.402 Å) | Cite: | The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7Y96
| |
5EG1
| Antibacterial peptide ABC transporter McjD with a resolved lipid | Descriptor: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, MAGNESIUM ION, Microcin-J25 export ATP-binding/permease protein McjD, ... | Authors: | Choudhury, H.G, Beis, K. | Deposit date: | 2015-10-26 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD. J.Biol.Chem., 291, 2016
|
|
6YOV
| OCT4-SOX2-bound nucleosome - SHL+6 | Descriptor: | DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2020-04-15 | Release date: | 2020-05-06 | Last modified: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
|
|
5C51
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA, DNA (5'-D(*(AD)P*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Whitney, Y.Y. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2016-05-18 | Method: | X-RAY DIFFRACTION (3.426 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
8JVJ
| Structure of human TRPV4 with antagonist A2 and RhoA | Descriptor: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
4W6D
| Crystal Structure of Full-Length Split GFP Mutant K26C Disulfide Dimer, P 32 2 1 Space Group, Form 1 | Descriptor: | MAGNESIUM ION, fluorescent protein K26C | Authors: | Leibly, D.J, Waldo, G.S, Yeates, T.O. | Deposit date: | 2014-08-20 | Release date: | 2015-02-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | A Suite of Engineered GFP Molecules for Oligomeric Scaffolding. Structure, 23, 2015
|
|
8JU6
| Structure of human TRPV4 with antagonist GSK279 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8S8D
| Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | Authors: | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | Deposit date: | 2024-03-06 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis of AUC codon discrimination during translation initiation in yeast. Nucleic Acids Res., 2024
|
|
6ITC
| Structure of a substrate engaged SecA-SecY protein translocation machine | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Ma, C.Y, Wu, X.F, Sun, D.J, Park, E.Y, Rapoport, T.A, Gao, N, Long, L. | Deposit date: | 2018-11-21 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure of the substrate-engaged SecA-SecY protein translocation machine. Nat Commun, 10, 2019
|
|
5DGE
| Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-27 | Release date: | 2017-01-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
|
|
3JAH
| Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | Deposit date: | 2015-06-10 | Release date: | 2015-08-12 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
|
|
4U56
| Crystal structure of Blasticidin S bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
3JAM
| CryoEM structure of 40S-eIF1A-eIF1 complex from yeast | Descriptor: | 18S rRNA, MAGNESIUM ION, RACK1, ... | Authors: | Llacer, J.L, Hussain, T, Ramakrishnan, V. | Deposit date: | 2015-06-17 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Mol.Cell, 59, 2015
|
|
5LZZ
| Structure of the mammalian rescue complex with Pelota and Hbs1l (combined) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | Deposit date: | 2016-10-02 | Release date: | 2016-11-30 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167, 2016
|
|