6ZBV

Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7

Summary for 6ZBV

• Entry DOI: 10.2210/pdb6zbv/pdb
• Related: 6ZPL
• Descriptor: Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone (3 entities in total)
• Functional Keywords: secondary active transport, neurotransmitter-sodium symport, amino acid transport, slc6a9, inward open state, inhibitor bound complex, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 78672.67

Authors

Shahsavar, A.,Stohler, P.,Bourenkov, G.,Zimmermann, I.,Siegrist, M.,Guba, W.,Pinard, E.,Sinning, S.,Seeger, M.A.,Schneider, T.R.,Dawson, R.J.P.,Nissen, P. (deposition date: 2020-06-09, release date: 2021-03-17, Last modification date: 2024-01-24)

• Primary citation: Shahsavar, A.,Stohler, P.,Bourenkov, G.,Zimmermann, I.,Siegrist, M.,Guba, W.,Pinard, E.,Sinning, S.,Seeger, M.A.,Schneider, T.R.,Dawson, R.J.P.,Nissen, P.; Structural insights into the inhibition of glycine reuptake.; Nature, 591:677-681, 2021; PubMed: 33658720; DOI: 10.1038/s41586-021-03274-z

Experimental method

X-RAY DIFFRACTION (3.4 Å)