6ZBV
Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1 | polymer | 577 | 64801.5 | 1 | UniProt (P48067) Pfam (PF00209) | Homo sapiens (Human) | GlyT1,Solute carrier family 6 member 9,GlyT1,Solute carrier family 6 member 9 |
| 2 | B (B) | Sybody Sb_GlyT1#7 | polymer | 120 | 13303.7 | 1 | unidentified | ||
| 3 | C (A) | [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone | non-polymer | 567.5 | 1 | Chemie (QET) |
Sequence modifications
A: 91 - 239 (UniProt: P48067)
A: 257 - 684 (UniProt: P48067)
| PDB | External Database | Details |
|---|---|---|
| Ala 153 | Leu 153 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 297 | Ser 297 | engineered mutation |
| Ala 368 | Ile 368 | engineered mutation |
| Ala 633 | Cys 633 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78105.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 567.5 | |
| All* | Total formula weight | 78672.7 |
