5C51

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

Summary for 5C51

• Entry DOI: 10.2210/pdb5c51/pdb
• Related: 5C52
• Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, DNA (5'-D(*(AD)P*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... (6 entities in total)
• Functional Keywords: nucleoside reverse transcriptase inhibitors (nrtis), hiv rt, human mitochondrial dna polymerase, mitochondrial toxicity, drug efficacy and toxicity, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Mitochondrion : P54098 Q9UHN1
• Total number of polymer chains: 5
• Total formula weight: 261003.65

Authors

Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Whitney, Y.Y. (deposition date: 2015-06-19, release date: 2016-05-11, Last modification date: 2016-05-18)

• Primary citation: Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Yin, Y.W.; Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.; Proc.Natl.Acad.Sci.USA, 112:8596-8601, 2015; PubMed: 26124101; DOI: 10.1073/pnas.1421733112

Experimental method

X-RAY DIFFRACTION (3.426 Å)