5ZYA
| SF3b spliceosomal complex bound to E7107 | Descriptor: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | Authors: | Finci, L.I, Larsen, N.A. | Deposit date: | 2018-05-23 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action Genes Dev., 32, 2018
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6SWA
| Mus musculus brain neocortex ribosome 60S bound to Ebp1 | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kraushar, M.L, Sprink, T. | Deposit date: | 2019-09-20 | Release date: | 2020-09-30 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Mol.Cell, 81, 2021
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1KPS
| Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1 | Descriptor: | Ran-GTPase activating protein 1, SULFATE ION, Ubiquitin-like protein SUMO-1 conjugating enzyme | Authors: | Bernier-Villamor, V, Sampson, D.A, Matunis, M.J, Lima, C.D. | Deposit date: | 2002-01-02 | Release date: | 2002-02-13 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell(Cambridge,Mass.), 108, 2002
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8BPA
| Cryo-EM structure of the human SIN3B histone deacetylase complex at 3.7 Angstrom | Descriptor: | CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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8BPB
| Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom | Descriptor: | ACETATE ION, CALCIUM ION, Histone deacetylase 2, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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8BPC
| Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom | Descriptor: | CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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1WYW
| Crystal Structure of SUMO1-conjugated thymine DNA glycosylase | Descriptor: | CHLORIDE ION, G/T mismatch-specific thymine DNA glycosylase, MAGNESIUM ION, ... | Authors: | Baba, D, Maita, N, Jee, J.G, Uchimura, Y, Saitoh, H, Sugasawa, K, Hanaoka, F, Tochio, H, Hiroaki, H, Shirakawa, M. | Deposit date: | 2005-02-17 | Release date: | 2005-06-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. Nature, 435, 2005
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5Z58
| Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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6Z2J
| The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-05-16 | Release date: | 2020-07-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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7ONB
| Structure of the U2 5' module of the A3'-SSA complex | Descriptor: | MINX, PHD finger-like domain-containing protein 5A, RNU2, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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6Z2K
| The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-05-16 | Release date: | 2020-07-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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7AEA
| Cryo-EM structure of human RNA Polymerase III elongation complex 2 | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | Deposit date: | 2020-09-17 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7ABI
| Human pre-Bact-2 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7AE3
| Cryo-EM structure of human RNA Polymerase III elongation complex 3 | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | Deposit date: | 2020-09-17 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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8I0S
| The cryo-EM structure of human Bact-II complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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7Q4O
| Substrate-bound A-like U2 snRNP | Descriptor: | BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7Q4P
| U2 snRNP after ATP-dependent remodelling | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.15 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7A6H
| Cryo-EM structure of human apo RNA Polymerase III | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | Deposit date: | 2020-08-25 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7AE1
| Cryo-EM structure of human RNA Polymerase III elongation complex 1 | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | Deposit date: | 2020-09-17 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7AO9
| Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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8IUH
| RNA polymerase III pre-initiation complex open complex 1 | Descriptor: | DNA (81-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | Authors: | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | Deposit date: | 2023-03-24 | Release date: | 2023-05-24 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Cell Res., 33, 2023
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6JLB
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7Z6O
| X-Ray studies of Ku70/80 reveal the binding site for IP6 | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Varela, P.F, Charbonnier, J.B. | Deposit date: | 2022-03-14 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
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3EAY
| Crystal structure of the human SENP7 catalytic domain | Descriptor: | SULFATE ION, Sentrin-specific protease 7 | Authors: | Lima, C.D, Reverter, D. | Deposit date: | 2008-08-26 | Release date: | 2008-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7. J.Biol.Chem., 283, 2008
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7D58
| cryo-EM structure of human RNA polymerase III in elongating state | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | Authors: | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | Deposit date: | 2020-09-25 | Release date: | 2021-02-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into transcriptional regulation of human RNA polymerase III. Nat.Struct.Mol.Biol., 28, 2021
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