PDB: 618 resultsInfo pagesStatus searchChemie searchBIRD

---

8F80	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 Descriptor: 1,2-ETHANEDIOL, 3-[2-(3-{[2,4-diamino-6-(4-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-11-21 Release date: 2023-12-13 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 To be published
8F81	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 Descriptor: 3-(2-{3-[(2,4-diamino-6-pentylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-11-21 Release date: 2023-12-13 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 To be published
5U27	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor Descriptor: 1,2-ETHANEDIOL, 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-11-29 Release date: 2016-12-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor TO BE PUBLISHED
5UJX	Crystal structure of DHFR in 20% Isopropanol Descriptor: CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... Authors: Cuneo, M.J, Agarwal, P.K. Deposit date: 2017-01-19 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Modulating Enzyme Activity by Altering Protein Dynamics with Solvent. Biochemistry, 57, 2018
5UII	structure of DHFR with bound buformin and NADP Descriptor: CALCIUM ION, Dihydrofolate reductase, N-butyl-N'-(diaminomethylidene)guanidine, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2018-01-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.351 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UJF	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor Descriptor: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-01-17 Release date: 2017-02-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor TO BE PUBLISHED
5UIO	structure of DHFR with bound DAP, p-ABG and NADP Descriptor: BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FORMIC ACID, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.929 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
8SSX	Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution Descriptor: 1,2-ETHANEDIOL, Dihydrofolate reductase, SULFATE ION Authors: Shaw, G.X, Li, Y, Wu, Y, Yan, H, Ji, X. Deposit date: 2023-05-09 Release date: 2023-05-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution To be published
5W3Q	L28F E.coli DHFR in complex with NADPH Descriptor: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Oyen, D, Wright, P.E, Wilson, I.A. Deposit date: 2017-06-08 Release date: 2017-08-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.401 Å) Cite: Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
8TBR	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758 Descriptor: 3-(2-{3-[(2,4-diamino-6-phenylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-29 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758 To be published
8TA1	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907 Descriptor: 3-(2-{3-[(2,4-diamino-6-cyclohexylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ACETATE ION, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-26 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907 To be published
5UIH	structure of DHFR with bound phenformin and NADP Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dihydrofolate reductase, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.647 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
8TA0	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881 Descriptor: 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-26 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881 To be published
8UCX	Dihydrofolate Reductase Complexed with Folate Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION Authors: Fried, S.D.E, Boxer, S.G. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Role of Electrostatics in Hydride Transfer by Dihydrofolate Reductase To Be Published
7DFR	CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Bystroff, C, Oatley, S.J, Kraut, J. Deposit date: 1988-10-21 Release date: 1990-07-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state. Biochemistry, 29, 1990
7D49	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-23 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.651 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D3Z	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-21 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D4X	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-24 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D6G	Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-30 Release date: 2021-06-09 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.65 Å), X-RAY DIFFRACTION Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D4L	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0 Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-24 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
5UIP	structure of DHFR with bound DAP, p-ABG and NADP Descriptor: Dihydrofolate reductase, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
8SZE	Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dihydrofolate reductase, ... Authors: Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. Deposit date: 2023-05-29 Release date: 2023-06-07 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim To be published
8SZD	Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution Descriptor: CHLORIDE ION, Dihydrofolate reductase, MAGNESIUM ION, ... Authors: Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. Deposit date: 2023-05-29 Release date: 2023-06-07 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution To be published
5U26	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor Descriptor: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-11-29 Release date: 2016-12-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor TO BE PUBLISHED
8UVZ	Bacillus subtilis DHFR bound to NADP+ and folate Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Smith, N, Horswill, A.R, Wilson, M.A. Deposit date: 2023-11-05 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Bacillus subtilis DHFR bound to NADP+ and folate To Be Published

<12345678910111213141516>