5U26

Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor

Summary for 5U26

• Entry DOI: 10.2210/pdb5u26/pdb
• Descriptor: Dihydrofolate reductase, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: dhfr, folate, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 21190.37

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2016-11-29, release date: 2016-12-21, Last modification date: 2023-10-04)

• Primary citation: Mayclin, S.J.,Fairman, J.W.,Lorimer, D.D.,Edwards, T.E.; Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.85 Å)