1RD4
| An allosteric inhibitor of LFA-1 bound to its I-domain | Descriptor: | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE, Integrin alpha-L | Authors: | Crump, M.P, Ceska, T.A, Spyracopoulos, L, Henry, A, Archibald, S.C, Alexander, R, Taylor, R.J, Findlow, S.C, O'Connell, J, Robinson, M.K, Shock, A. | Deposit date: | 2003-11-05 | Release date: | 2004-03-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry Biochemistry, 43, 2004
|
|
1SHT
| Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor | Descriptor: | ACETATE ION, Anthrax toxin receptor 2, MAGNESIUM ION | Authors: | Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J. | Deposit date: | 2004-02-26 | Release date: | 2004-04-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1SHU
| Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor | Descriptor: | Anthrax toxin receptor 2, MAGNESIUM ION | Authors: | Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J. | Deposit date: | 2004-02-26 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
8CE9
| Crystal structure of human Cd11b I domain in C121 space group | Descriptor: | 1,2-ETHANEDIOL, Integrin alpha-M, SULFATE ION | Authors: | Koekemoer, L, Williams, E, Ni, X, Gao, Q, Coker, J, MacLean, E.M, Wright, N.D, Marsden, B, Von Delft, F, Schwenzer, A, Midwood, K. | Deposit date: | 2023-02-01 | Release date: | 2023-03-22 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Crystal structure of human Cd11b I domain in C121 space group To Be Published
|
|
8CE6
| Crystal structure of human Cd11b I domain in P212121 space group | Descriptor: | CHLORIDE ION, GLYCEROL, Integrin alpha-M, ... | Authors: | Koekemoer, L, Williams, E, Ni, X, Gao, Q, Coker, J, MacLean, E.M, Wright, N.D, Marsden, B, Von Delft, F, Schwenzer, A, Midwood, K. | Deposit date: | 2023-02-01 | Release date: | 2023-03-22 | Last modified: | 2023-04-12 | Method: | X-RAY DIFFRACTION (1.582 Å) | Cite: | Crystal structure of human Cd11b I domain in P212121 space group To Be Published
|
|
1IDO
| I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND | Descriptor: | INTEGRIN, MAGNESIUM ION | Authors: | Lee, J.-O, Liddington, R. | Deposit date: | 1996-03-12 | Release date: | 1996-08-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell(Cambridge,Mass.), 80, 1995
|
|
1IDN
| MAC-1 I DOMAIN METAL FREE | Descriptor: | CD11B | Authors: | Baldwin, E.T. | Deposit date: | 1998-06-10 | Release date: | 1998-11-04 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cation binding to the integrin CD11b I domain and activation model assessment Structure, 6, 1998
|
|
1IJB
| The von Willebrand Factor mutant (I546V) A1 domain | Descriptor: | von Willebrand factor | Authors: | Fukuda, K, Doggett, T.A, Bankston, L.A, Cruz, M.A, Diacovo, T.G, Liddington, R.C. | Deposit date: | 2001-04-25 | Release date: | 2002-07-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure, 10, 2002
|
|
1JLM
| I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND | Descriptor: | INTEGRIN, MANGANESE (II) ION | Authors: | Lee, J.-O, Liddington, R. | Deposit date: | 1996-04-09 | Release date: | 1997-01-11 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure, 3, 1995
|
|
1LFA
| CD11A I-DOMAIN WITH BOUND MN++ | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1995-09-08 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc.Natl.Acad.Sci.USA, 92, 1995
|
|
1MHP
| Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody | Descriptor: | FAB FRAGMENT, light chain, Fab fragment, ... | Authors: | Karpusas, M, Taylor, F, Ferrant, J, Weinreb, P, Garber, E. | Deposit date: | 2002-08-20 | Release date: | 2003-04-15 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the alpha 1 beta 1 Integrin I Domain in Complex with
an Antibody Fab Fragment J.Mol.Biol., 327, 2003
|
|
1MJN
| Crystal Structure of the intermediate affinity aL I domain mutant | Descriptor: | Integrin alpha-L, MAGNESIUM ION | Authors: | Shimaoka, M, Xiao, T, Liu, J.H, Yang, Y.T, Dong, Y.C, Jun, C.D, McCormack, A, Zhang, R.G, Wang, J.H, Springer, T.A. | Deposit date: | 2002-08-28 | Release date: | 2003-01-28 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation Cell(Cambridge,Mass.), 112, 2003
|
|
1M1U
| AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN | Descriptor: | CALCIUM ION, Integrin alpha-M | Authors: | Xiong, J.-P, Li, R, Essafi, M, Stehle, T, Arnaout, M.A. | Deposit date: | 2002-06-20 | Release date: | 2002-08-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J.Biol.Chem., 275, 2000
|
|
1MQA
| Crystal structure of high affinity alphaL I domain in the absence of ligand or metal | Descriptor: | Integrin alpha-L | Authors: | Shimaoka, T, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, Zhang, R, Takagi, J, Wang, J.-H, Springer, T.A. | Deposit date: | 2002-09-15 | Release date: | 2003-01-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation Cell(Cambridge,Mass.), 112, 2003
|
|
1MF7
| INTEGRIN ALPHA M I DOMAIN | Descriptor: | INTEGRIN ALPHA M | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-08-09 | Release date: | 2003-05-20 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
|
|
1MQ9
| Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact | Descriptor: | Integrin alpha-L, MANGANESE (II) ION | Authors: | Shimaoka, M, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, McCormack, A, Zhang, R, Joachimiak, A, Takagi, J, Wang, J.-H, Springer, T.A. | Deposit date: | 2002-09-15 | Release date: | 2003-01-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation Cell(Cambridge,Mass.), 112, 2003
|
|
1N3Y
| Crystal structure of the alpha-X beta2 integrin I domain | Descriptor: | Integrin alpha-X | Authors: | Vorup-Jensen, T, Ostermeier, C, Shimaoka, M, Hommel, U, Springer, T.A. | Deposit date: | 2002-10-30 | Release date: | 2003-02-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
1N9Z
| INTEGRIN ALPHA M I DOMAIN MUTANT | Descriptor: | Integrin alpha-M, MAGNESIUM ION | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-11-26 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
|
|
1NA5
| INTEGRIN ALPHA M I DOMAIN | Descriptor: | Integrin alpha-M | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-11-26 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
|
|
7YG5
| |
2ADF
| Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain | Descriptor: | 82D6A3 IgG, ACETIC ACID, GLYCEROL, ... | Authors: | Staelens, S, Hadders, M.A, Vauterin, S, Platteau, C, Vanhoorelbeke, K, Huizinga, E.G, Deckmyn, H. | Deposit date: | 2005-07-20 | Release date: | 2005-12-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain J.Biol.Chem., 281, 2006
|
|
6FPY
| Inter-alpha-inhibitor heavy chain 1, wild type | Descriptor: | GLYCEROL, Inter-alpha-trypsin inhibitor heavy chain H1, MAGNESIUM ION | Authors: | Briggs, D.C, Day, A.J. | Deposit date: | 2018-02-12 | Release date: | 2019-02-27 | Last modified: | 2020-03-18 | Method: | X-RAY DIFFRACTION (2.339 Å) | Cite: | Inter-alpha-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation J.Biol.Chem., 2020
|
|
6FPZ
| Inter-alpha-inhibitor heavy chain 1, D298A | Descriptor: | ACETATE ION, GLYCEROL, Inter-alpha-trypsin inhibitor heavy chain H1 | Authors: | Briggs, D.C, Day, A.J. | Deposit date: | 2018-02-12 | Release date: | 2019-02-27 | Last modified: | 2020-03-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inter-alpha-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation J.Biol.Chem., 2020
|
|
7ZWH
| VWF Tubules of D1D2 and D'D3A1 domains | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Javitt, G, Fass, D. | Deposit date: | 2022-05-19 | Release date: | 2022-07-13 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion. Blood, 140, 2022
|
|
7AKK
| Structure of a complement factor-receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | Authors: | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | Deposit date: | 2020-10-01 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.395 Å) | Cite: | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor Nat Commun, 13, 2022
|
|