PDB: 35140 resultsInfo pagesStatus searchChemie searchBIRD

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4OIV	Structural basis for small molecule NDB as a selective antagonist of FXR Descriptor: Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide Authors: Xu, X, Chen, L, Hu, L, Shen, X. Deposit date: 2014-01-20 Release date: 2015-03-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor. J.Biol.Chem., 290, 2015
4A28	Eg5-2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION Authors: Talapatra, S.K, Kozielski, F. Deposit date: 2011-09-22 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
3US5	Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.38 A resolution Descriptor: CHLORIDE ION, Poly(U)-binding-splicing factor PUF60 Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.38 A resolution To be published
4A0C	Structure of the CAND1-CUL4B-RBX1 complex Descriptor: CULLIN-4B, CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1, E3 UBIQUITIN-PROTEIN LIGASE RBX1, ... Authors: Scrima, A, Fischer, E.S, Faty, M, Gut, H, Thoma, N.H. Deposit date: 2011-09-08 Release date: 2011-11-30 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.8 Å) Cite: The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
4A5Y	Intermediate state of human kinesin Eg5 in complex with Ispinesib Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ... Authors: Kaan, H.Y.K, Kozielski, F. Deposit date: 2011-10-29 Release date: 2012-11-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: "Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5. J.Biol.Chem., 288, 2013
4NDY	Human MHF1-MHF2 DNA complex Descriptor: Centromere protein S, Centromere protein X, DNA (26-MER) Authors: Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. Deposit date: 2013-10-28 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (6.999 Å) Cite: The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
4NE1	Human MHF1 MHF2 DNA complexes Descriptor: Centromere protein S, Centromere protein X, DNA (26-MER) Authors: Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. Deposit date: 2013-10-28 Release date: 2014-01-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (6.499 Å) Cite: The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
4NE3	Human MHF1-MHF2 complex Descriptor: Centromere protein S, Centromere protein X Authors: Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. Deposit date: 2013-10-28 Release date: 2013-12-25 Last modified: 2014-02-12 Method: X-RAY DIFFRACTION (1.8007 Å) Cite: The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
4A51	Crystal structure of human kinesin Eg5 in complex with 1-(3-(((2-Aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride Descriptor: 1-(3-{[(2-aminoethyl)sulfanyl](diphenyl)methyl}phenyl)ethanone, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Kaan, H.Y.K, Kozielski, F. Deposit date: 2011-10-24 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity. J.Med.Chem., 55, 2012
4A50	Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid Descriptor: (2R)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, (2S)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Kaan, H.Y.K, Kozielski, F. Deposit date: 2011-10-24 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity. J.Med.Chem., 55, 2012
4NE6	Human MHF1-MHF2 complex Descriptor: Centromere protein S, Centromere protein X Authors: Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. Deposit date: 2013-10-28 Release date: 2013-12-25 Last modified: 2014-02-12 Method: X-RAY DIFFRACTION (2.1001 Å) Cite: The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
4B7B	Eg5-3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CALCIUM ION, ... Authors: Talapatra, S.K, Kozielski, F. Deposit date: 2012-08-17 Release date: 2013-07-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
4U0U	Wild type eukaryotic fic domain containing protein with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Adenosine monophosphate-protein transferase FICD, MAGNESIUM ION, ... Authors: Cole, A.R, Bunney, T.D, Katan, M. Deposit date: 2014-07-14 Release date: 2014-12-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure, 22, 2014
4NE5	Human MHF1-MHF2 complex Descriptor: Centromere protein S, Centromere protein X Authors: Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. Deposit date: 2013-10-28 Release date: 2013-12-25 Last modified: 2014-02-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
3GPD	TWINNING IN CRYSTALS OF HUMAN SKELETAL MUSCLE D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE Descriptor: D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION Authors: Watson, H.C, Campbell, J.C. Deposit date: 1983-06-20 Release date: 1983-10-27 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase. J.Mol.Biol., 104, 1976
5XJS	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.38 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
5XJT	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Structures of 7S mutant complexes To Be Published
5XUQ	Crystal structure of VDR-LBD complexed with an antagonist, 2-methylidene-19,26,27-trinor-22-(S)-butyl-1-hydroxy-25-oxo-25-(1H-pyrrol-2-yl)- vitamin D3 Descriptor: (4~{S})-4-[(1~{R})-1-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]ethyl]-1-(1~{H}-pyrrol-2-yl)octan-1-one, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor Authors: Kato, A, Itoh, T, Yamamoto, K. Deposit date: 2017-06-24 Release date: 2018-06-27 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery of Potent Vitamin D Receptor Antagonist To Be Published
5XBL	Structure of nuclease in complex with associated protein Descriptor: Associated protein, CRISPR-associated endonuclease Cas9/Csn1, RNA (98-MER) Authors: Dong, D, Guo, M, Wang, S, Zhu, Y, Huang, Z. Deposit date: 2017-03-20 Release date: 2017-06-14 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.052 Å) Cite: Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein Nature, 546, 2017
5XJR	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
3I6M	3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine Descriptor: (4aS,6R,8aS)-3-methoxy-11-(3-piperidin-1-ylpropyl)-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Lamba, D, Bartolucci, C. Deposit date: 2009-07-07 Release date: 2010-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53, 2010
5XPO	Crystal structure of VDR-LBD complexed with 25-(hydroxyphenyl)-2-methylidene-19,26,27-trinor-25-oxo-1-hydroxyvitamin D3 Descriptor: (5~{R})-5-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexyl idene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]-1-(4-hydroxyphenyl)hexan-1-one, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor Authors: Kato, A, Itoh, T, Yamamoto, K. Deposit date: 2017-06-03 Release date: 2018-06-06 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action J. Med. Chem., 60, 2017
7VVG	Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Zheng, Y.Y, Zhou, C. Deposit date: 2021-11-06 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VV8	Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Zheng, Y.Y, Zhou, C. Deposit date: 2021-11-04 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
5XJQ	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.28 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019

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