4A5Y

Intermediate state of human kinesin Eg5 in complex with Ispinesib

Summary for 4A5Y

Entry DOI	10.2210/pdb4a5y/pdb
Related	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 4A1Z 4A28 4A50 4A51
Descriptor	KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	motor protein, mitosis
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P52732
Total number of polymer chains	3
Total formula weight	126284.69
Authors	Kaan, H.Y.K.,Kozielski, F. (deposition date: 2011-10-29, release date: 2012-11-07, Last modification date: 2023-12-20)
Primary citation	Kaan, H.Y.K.,Major, J.,Tkocz, K.,Kozielski, F.,Rosenfeld, S.S. "Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5. J.Biol.Chem., 288:18588-, 2013 Cited by PubMed: 23658017 DOI: 10.1074/JBC.M113.462648 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation