4A5Y

Intermediate state of human kinesin Eg5 in complex with Ispinesib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003777	molecular_function	microtubule motor activity
A	0005524	molecular_function	ATP binding
A	0007018	biological_process	microtubule-based movement
A	0008017	molecular_function	microtubule binding
B	0003777	molecular_function	microtubule motor activity
B	0005524	molecular_function	ATP binding
B	0007018	biological_process	microtubule-based movement
B	0008017	molecular_function	microtubule binding
C	0003777	molecular_function	microtubule motor activity
C	0005524	molecular_function	ATP binding
C	0007018	biological_process	microtubule-based movement
C	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 601

Chain	Residue
A	ARG24
A	GLU118
A	HOH2004
A	HOH2006
A	ARG26
A	PRO27
A	THR107
A	GLY108
A	GLY110
A	LYS111
A	THR112
A	PHE113

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP B 601

Chain	Residue
B	ARG24
B	ARG26
B	PRO27
B	THR107
B	GLY108
B	GLY110
B	LYS111
B	THR112
B	PHE113
B	GLU118
B	HOH2004
B	HOH2080
B	HOH2081

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP C 601

Chain	Residue
C	ARG26
C	PRO27
C	GLY108
C	THR109
C	GLY110
C	LYS111
C	THR112
C	PHE113
C	GLU118
C	ILE250
C	MG1365
C	HOH2005
C	HOH2028
C	HOH2052
C	HOH2054
C	HOH2058
C	HOH2128

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1365

Chain	Residue
C	THR112
C	ASP265
C	ADP601
C	HOH2128

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 C 1366

Chain	Residue
B	HIS141
B	GLU145
B	LYS207
C	ASP186
C	ARG312
C	ARG318
C	HOH2100
C	HOH2153
C	HOH2168

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 1367

Chain	Residue
C	ARG53
C	HIS141
C	GLU145

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1364

Chain	Residue
A	ARG53
A	HIS141
A	LYS207

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1368

Chain	Residue
A	GLY198
C	GLY198

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE G7X A 1365

Chain	Residue
A	GLU116
A	GLU118
A	TRP127
A	ILE136
A	PRO137
A	LEU160
A	TYR211
A	LEU214
A	GLY217
A	ARG221

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE G7X B 1363

Chain	Residue
B	GLU116
B	GLY117
B	GLU118
B	TRP127
B	ILE136
B	LEU160
B	TYR211
B	LEU214
B	GLY217
B	ALA218
B	ARG221
B	HOH2014

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE G7X C 1369

Chain	Residue
C	HOH2059
C	HOH2122
C	GLU116
C	GLY117
C	GLU118
C	ARG119
C	TRP127
C	ALA133
C	ILE136
C	PRO137
C	LEU160
C	TYR211
C	LEU214
C	GLU215
C	GLY217
C	ARG221

---

Functional Information from PROSITE/UniProt

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE

Chain	Residue	Details
A	GLY259-GLU270

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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