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5XPO

Crystal structure of VDR-LBD complexed with 25-(hydroxyphenyl)-2-methylidene-19,26,27-trinor-25-oxo-1-hydroxyvitamin D3

Summary for 5XPO
Entry DOI10.2210/pdb5xpo/pdb
DescriptorVitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (5~{R})-5-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexyl idene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]-1-(4-hydroxyphenyl)hexan-1-one, ... (4 entities in total)
Functional Keywordstranscription, vitamin d3, vdr, vdre, rxr, co-factors
Biological sourceRattus norvegicus (Rat)
More
Total number of polymer chains2
Total formula weight32644.60
Authors
Kato, A.,Itoh, T.,Yamamoto, K. (deposition date: 2017-06-03, release date: 2018-06-06, Last modification date: 2024-03-27)
Primary citationKato, A.,Yamao, M.,Hashihara, Y.,Ishida, H.,Itoh, T.,Yamamoto, K.
Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action
J. Med. Chem., 60:8394-8406, 2017
Cited by
PubMed: 28954197
DOI: 10.1021/acs.jmedchem.7b00819
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.28 Å)
Structure validation

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