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4YDH
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BU of 4ydh by Molmil
The structure of human FMNL1 N-terminal domains bound to Cdc42
Descriptor: Cell division control protein 42 homolog, Formin-like protein 1, MAGNESIUM ION, ...
Authors:Kuhn, S, Anand, K, Geyer, M.
Deposit date:2015-02-22
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.
Nat Commun, 6, 2015
4WVF
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BU of 4wvf by Molmil
Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Descriptor: (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Sun, Q, Chook, Y.
Deposit date:2014-11-05
Release date:2015-07-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015
4YC7
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BU of 4yc7 by Molmil
Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp
Descriptor: Cell division control protein 42 homolog, Formin-like protein 2, MAGNESIUM ION, ...
Authors:Kuhn, S, Geyer, M.
Deposit date:2015-02-19
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.
Nat Commun, 6, 2015
7QTM
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BU of 7qtm by Molmil
Transition state analogue of small G protein in complex with relevant GAP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ...
Authors:Baumann, P, Jin, Y.
Deposit date:2022-01-14
Release date:2023-01-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Transition state analogue of small G protein in complex with relevant GAP
To Be Published
7S0Y
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BU of 7s0y by Molmil
Structures of TcdB in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zheng, L, Rongsheng, J, Peng, C.
Deposit date:2021-08-31
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B.
Sci Adv, 7, 2021
7S0Z
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BU of 7s0z by Molmil
Structures of TcdB in complex with R-Ras
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, AMMONIUM ION, ...
Authors:Zheng, L, Rongsheng, J, Peng, C.
Deposit date:2021-08-31
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B.
Sci Adv, 7, 2021
7RSE
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BU of 7rse by Molmil
NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B.
Deposit date:2021-08-11
Release date:2021-09-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
7RSC
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BU of 7rsc by Molmil
NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B.
Deposit date:2021-08-11
Release date:2021-09-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
5OEC
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BU of 5oec by Molmil
Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ...
Authors:Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A.
Deposit date:2017-07-07
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.
Nat Commun, 9, 2018
5O33
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BU of 5o33 by Molmil
A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ...
Authors:Gray, J, Krojer, T, Talon, R, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P, von Delft, F.
Deposit date:2017-05-23
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
To Be Published
5O74
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BU of 5o74 by Molmil
Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Multifunctional virulence effector protein DrrA, Ras-related protein Rab-1B
Authors:Cigler, M, Mueller, T, Horn-Ghetko, D, von Wrisberg, M.K, Fottner, M, Goody, R.S, Itzen, A, Mueller, M.P, Lang, K.
Deposit date:2017-06-08
Release date:2017-10-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OED
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BU of 5oed by Molmil
Human Rab32:GDP in complex with Salmonella GtgE C45A mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ...
Authors:Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A.
Deposit date:2017-07-07
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.
Nat Commun, 9, 2018
8ITV
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BU of 8itv by Molmil
KL2.1 in complex with CRM1-Ran-RanBP1
Descriptor: (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Sun, Q, Jian, L.
Deposit date:2023-03-23
Release date:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:KL2.1 in complex with CRM1-Ran-RanBP1
To Be Published
1AM4
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BU of 1am4 by Molmil
COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS)
Descriptor: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ...
Authors:Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J.
Deposit date:1997-06-22
Release date:1998-07-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature, 388, 1997
8KB8
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BU of 8kb8 by Molmil
Structure of the WDR91 WD40 domain complexed with Rab7
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ...
Authors:Li, J, Ma, X.L, Banerjee, S, Dong, Z.G.
Deposit date:2023-08-04
Release date:2024-08-07
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Insights into the distinct membrane targeting mechanisms of WDR91 family proteins.
Structure, 32, 2024
8P3K
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BU of 8p3k by Molmil
Fusion hSlp2-a_Rab27A non-covalent complex with compound IMP-2505
Descriptor: (2~{S})-~{N}-(3-methoxyphenyl)-1-[4-(prop-2-enoylamino)phenyl]sulfonyl-pyrrolidine-2-carboxamide, GLYCEROL, MAGNESIUM ION, ...
Authors:De Vita, E, Brustur, D, Tersa, M, Petracca, R, Morgan, R.M.L, Lanyon-Hogg, T, Norman, J.C, Cota, E, Tate, E.W.
Deposit date:2023-05-17
Release date:2024-11-20
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Targeted covalent inhibitors of the small GTPase Rab27A
To Be Published
1BKD
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BU of 1bkd by Molmil
COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1
Descriptor: H-RAS, SON OF SEVENLESS-1
Authors:Boriack-Sjodin, P.A, Margarit, S.M, Sagi, D.B, Kuriyan, J.
Deposit date:1998-07-06
Release date:1999-01-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis of the activation of Ras by Sos.
Nature, 394, 1998
1C1Y
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BU of 1c1y by Molmil
CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).
Descriptor: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nassar, N.
Deposit date:1999-07-22
Release date:1999-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature, 375, 1995
3TW8
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BU of 3tw8 by Molmil
GEF domain of DENND 1B in complex with Rab GTPase Rab35
Descriptor: DENN domain-containing protein 1B, Ras-related protein Rab-35
Authors:Wu, X.D, Kummel, D, Reinisch, K.M.
Deposit date:2011-09-21
Release date:2011-11-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TNF
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BU of 3tnf by Molmil
LidA from Legionella in complex with active Rab8a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, LidA, MAGNESIUM ION, ...
Authors:Schoebel, S, Cichy, A.L, Goody, R.S, Itzen, A.
Deposit date:2011-09-01
Release date:2011-11-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protein LidA from Legionella is a Rab GTPase supereffector.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TSO
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BU of 3tso by Molmil
Structure of the cancer associated Rab25 protein in complex with FIP2
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Oda, S, Lall, P.Y, McCaffrey, M.W, Khan, A.R.
Deposit date:2011-09-13
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the cancer associated Rab25 protein in complex with FIP2
TO BE PUBLISHED
3T5G
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BU of 3t5g by Molmil
Structure of fully modified farnesylated Rheb in complex with PDE6D
Descriptor: FARNESYL, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Ismail, S.A, Chen, Y.-X, Wittinghofer, A.
Deposit date:2011-07-27
Release date:2011-10-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.
Nat.Chem.Biol., 7, 2011
3SUA
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BU of 3sua by Molmil
Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.39 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
2WBL
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BU of 2wbl by Molmil
Three-dimensional structure of a binary ROP-PRONE complex
Descriptor: RAC-LIKE GTP-BINDING PROTEIN ARAC2, RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8
Authors:Thomas, C, Fricke, I, Weyand, M, Berken, A.
Deposit date:2009-03-02
Release date:2009-04-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction.
Biol.Chem., 390, 2009
3SU8
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BU of 3su8 by Molmil
Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011

238582

數據於2025-07-09公開中

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