4YDH
 
 | The structure of human FMNL1 N-terminal domains bound to Cdc42 | Descriptor: | Cell division control protein 42 homolog, Formin-like protein 1, MAGNESIUM ION, ... | Authors: | Kuhn, S, Anand, K, Geyer, M. | Deposit date: | 2015-02-22 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation. Nat Commun, 6, 2015
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4WVF
 
 | Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1 | Descriptor: | (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Sun, Q, Chook, Y. | Deposit date: | 2014-11-05 | Release date: | 2015-07-15 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nat.Neurosci., 18, 2015
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4YC7
 
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7QTM
 
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7S0Y
 
 | Structures of TcdB in complex with Cdc42 | Descriptor: | Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zheng, L, Rongsheng, J, Peng, C. | Deposit date: | 2021-08-31 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Sci Adv, 7, 2021
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7S0Z
 
 | Structures of TcdB in complex with R-Ras | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, AMMONIUM ION, ... | Authors: | Zheng, L, Rongsheng, J, Peng, C. | Deposit date: | 2021-08-31 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Sci Adv, 7, 2021
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7RSE
 
 | NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | Authors: | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
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7RSC
 
 | NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | Authors: | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
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5OEC
 
 | Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ... | Authors: | Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A. | Deposit date: | 2017-07-07 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The protease GtgE from Salmonella exclusively targets inactive Rab GTPases. Nat Commun, 9, 2018
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5O33
 
 | A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ... | Authors: | Gray, J, Krojer, T, Talon, R, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P, von Delft, F. | Deposit date: | 2017-05-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 To Be Published
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5O74
 
 | Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Multifunctional virulence effector protein DrrA, Ras-related protein Rab-1B | Authors: | Cigler, M, Mueller, T, Horn-Ghetko, D, von Wrisberg, M.K, Fottner, M, Goody, R.S, Itzen, A, Mueller, M.P, Lang, K. | Deposit date: | 2017-06-08 | Release date: | 2017-10-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo. Angew. Chem. Int. Ed. Engl., 56, 2017
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5OED
 
 | Human Rab32:GDP in complex with Salmonella GtgE C45A mutant | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ... | Authors: | Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A. | Deposit date: | 2017-07-07 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The protease GtgE from Salmonella exclusively targets inactive Rab GTPases. Nat Commun, 9, 2018
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8ITV
 
 | KL2.1 in complex with CRM1-Ran-RanBP1 | Descriptor: | (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoic acid, ACETATE ION, CHLORIDE ION, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | KL2.1 in complex with CRM1-Ran-RanBP1 To Be Published
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1AM4
 
 | COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS) | Descriptor: | CDC42HS, MAGNESIUM ION, P50-RHOGAP, ... | Authors: | Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J. | Deposit date: | 1997-06-22 | Release date: | 1998-07-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature, 388, 1997
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8KB8
 
 | Structure of the WDR91 WD40 domain complexed with Rab7 | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... | Authors: | Li, J, Ma, X.L, Banerjee, S, Dong, Z.G. | Deposit date: | 2023-08-04 | Release date: | 2024-08-07 | Last modified: | 2024-12-18 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Insights into the distinct membrane targeting mechanisms of WDR91 family proteins. Structure, 32, 2024
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8P3K
 
 | Fusion hSlp2-a_Rab27A non-covalent complex with compound IMP-2505 | Descriptor: | (2~{S})-~{N}-(3-methoxyphenyl)-1-[4-(prop-2-enoylamino)phenyl]sulfonyl-pyrrolidine-2-carboxamide, GLYCEROL, MAGNESIUM ION, ... | Authors: | De Vita, E, Brustur, D, Tersa, M, Petracca, R, Morgan, R.M.L, Lanyon-Hogg, T, Norman, J.C, Cota, E, Tate, E.W. | Deposit date: | 2023-05-17 | Release date: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Targeted covalent inhibitors of the small GTPase Rab27A To Be Published
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1BKD
 
 | COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1 | Descriptor: | H-RAS, SON OF SEVENLESS-1 | Authors: | Boriack-Sjodin, P.A, Margarit, S.M, Sagi, D.B, Kuriyan, J. | Deposit date: | 1998-07-06 | Release date: | 1999-01-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structural basis of the activation of Ras by Sos. Nature, 394, 1998
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1C1Y
 
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3TW8
 
 | GEF domain of DENND 1B in complex with Rab GTPase Rab35 | Descriptor: | DENN domain-containing protein 1B, Ras-related protein Rab-35 | Authors: | Wu, X.D, Kummel, D, Reinisch, K.M. | Deposit date: | 2011-09-21 | Release date: | 2011-11-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TNF
 
 | LidA from Legionella in complex with active Rab8a | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, LidA, MAGNESIUM ION, ... | Authors: | Schoebel, S, Cichy, A.L, Goody, R.S, Itzen, A. | Deposit date: | 2011-09-01 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protein LidA from Legionella is a Rab GTPase supereffector. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TSO
 
 | Structure of the cancer associated Rab25 protein in complex with FIP2 | Descriptor: | GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Oda, S, Lall, P.Y, McCaffrey, M.W, Khan, A.R. | Deposit date: | 2011-09-13 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the cancer associated Rab25 protein in complex with FIP2 TO BE PUBLISHED
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3T5G
 
 | Structure of fully modified farnesylated Rheb in complex with PDE6D | Descriptor: | FARNESYL, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ismail, S.A, Chen, Y.-X, Wittinghofer, A. | Deposit date: | 2011-07-27 | Release date: | 2011-10-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat.Chem.Biol., 7, 2011
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3SUA
 
 | Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | Deposit date: | 2011-07-11 | Release date: | 2011-09-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.39 Å) | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling. Plos Biol., 9, 2011
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2WBL
 
 | Three-dimensional structure of a binary ROP-PRONE complex | Descriptor: | RAC-LIKE GTP-BINDING PROTEIN ARAC2, RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8 | Authors: | Thomas, C, Fricke, I, Weyand, M, Berken, A. | Deposit date: | 2009-03-02 | Release date: | 2009-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction. Biol.Chem., 390, 2009
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3SU8
 
 | Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | Deposit date: | 2011-07-11 | Release date: | 2011-09-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling. Plos Biol., 9, 2011
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