4WVF
Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Summary for 4WVF
Entry DOI | 10.2210/pdb4wvf/pdb |
Related | 4gmx |
Descriptor | GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Crm1p, ... (10 entities in total) |
Functional Keywords | crm1, inhibitor, sine, kpt, transport protein-transport protein inhibitor complex, transport protein/transport protein inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P62826 Cytoplasm: P41920 |
Total number of polymer chains | 3 |
Total formula weight | 159820.35 |
Authors | |
Primary citation | Haines, J.D.,Herbin, O.,de la Hera, B.,Vidaurre, O.G.,Moy, G.A.,Sun, Q.,Fung, H.Y.,Albrecht, S.,Alexandropoulos, K.,McCauley, D.,Chook, Y.M.,Kuhlmann, T.,Kidd, G.J.,Shacham, S.,Casaccia, P. Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nat.Neurosci., 18:511-520, 2015 Cited by PubMed: 25706475DOI: 10.1038/nn.3953 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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