4YC7
Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp
Summary for 4YC7
Entry DOI | 10.2210/pdb4yc7/pdb |
Descriptor | Formin-like protein 2, Cell division control protein 42 homolog, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | signaling protein, armadillo repeat, rho gtpase, cell cycle |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q96PY5 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P60953 |
Total number of polymer chains | 2 |
Total formula weight | 64655.65 |
Authors | |
Primary citation | Kuhn, S.,Erdmann, C.,Kage, F.,Block, J.,Schwenkmezger, L.,Steffen, A.,Rottner, K.,Geyer, M. The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation. Nat Commun, 6:7088-7088, 2015 Cited by PubMed: 25963737DOI: 10.1038/ncomms8088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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