5O74

Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP

Summary for 5O74

Entry DOI	10.2210/pdb5o74/pdb
Descriptor	Multifunctional virulence effector protein DrrA, Ras-related protein Rab-1B, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	rab1b, drra, exchange factor, legionella pneumophila, hydrolase
Biological source	Legionella pneumophila More
Cellular location	Secreted : Q29ST3 Cytoplasm : Q9H0U4
Total number of polymer chains	12
Total formula weight	258297.26
Authors	Cigler, M.,Mueller, T.,Horn-Ghetko, D.,von Wrisberg, M.K.,Fottner, M.,Goody, R.S.,Itzen, A.,Mueller, M.P.,Lang, K. (deposition date: 2017-06-08, release date: 2017-10-11, Last modification date: 2024-01-17)
Primary citation	Cigler, M.,Muller, T.G.,Horn-Ghetko, D.,von Wrisberg, M.K.,Fottner, M.,Goody, R.S.,Itzen, A.,Muller, M.P.,Lang, K. Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo. Angew. Chem. Int. Ed. Engl., 56:15737-15741, 2017 Cited by PubMed: 28960788 DOI: 10.1002/anie.201706927 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation