5O74
Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G, I... | Multifunctional virulence effector protein DrrA | polymer | 197 | 22001.2 | 6 | UniProt (Q29ST3) Pfam (PF20851) In PDB | Legionella pneumophila | Defects in Rab1 recruitment protein A |
2 | B, D, F, H, J... | Ras-related protein Rab-1B | polymer | 180 | 20605.1 | 6 | UniProt (Q9H0U4) Pfam (PF00071) In PDB | Homo sapiens (Human) | |
3 | B, D, F, H, J... | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 6 | Chemie (GDP) | Homo sapiens (Human) |
Sequence modifications
A, C, E, G, I, K: 340 - 533 (UniProt: Q29ST3)
B, D, F, H, J, L: 3 - 174 (UniProt: Q9H0U4)
PDB | External Database | Details |
---|---|---|
Gly 337 | - | expression tag |
His 338 | - | expression tag |
Met 339 | - | expression tag |
Cys 512 | Asp 512 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 2 | - | expression tag |
9mn 79 | Arg 79 | engineered mutation |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
His 179 | - | expression tag |
His 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 255638.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2659.2 | |
All* | Total formula weight | 258297.3 |