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8WG0
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BU of 8wg0 by Molmil
Crystal structure of GH97 glucodextranase from Flavobacterium johnsoniae in complex with glucose
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Candidate alpha-glucosidase Glycoside hydrolase family 97, ...
Authors:Kurata, R, Nakamura, S, Miyazaki, T.
Deposit date:2023-09-20
Release date:2024-05-08
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into alpha-(1→6)-linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae.
Febs J., 291, 2024
8WGT
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BU of 8wgt by Molmil
Crystal structure of V30M-TTR in complex with compound 7
Descriptor: Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone
Authors:Yokoyama, T.
Deposit date:2023-09-22
Release date:2024-05-15
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J.Med.Chem., 67, 2024
7RQE
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BU of 7rqe by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S.
Deposit date:2021-08-06
Release date:2022-01-26
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
7RQA
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BU of 7rqa by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, ...
Authors:Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S.
Deposit date:2021-08-06
Release date:2022-01-26
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
7PZY
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BU of 7pzy by Molmil
Structure of the vacant Candida albicans 80S ribosome
Descriptor: 1,4-DIAMINOBUTANE, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M.
Deposit date:2021-10-13
Release date:2022-05-18
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
8VTY
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BU of 8vty by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, 16S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
7P81
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BU of 7p81 by Molmil
Crystal structure of ClpP from Bacillus subtilis in complex with ADEP2 (compact state)
Descriptor: ADEP2, ATP-dependent Clp protease proteolytic subunit
Authors:Lee, B.-G, Kim, L, Kim, M.K, Kwon, D.H, Song, H.K.
Deposit date:2021-07-21
Release date:2022-06-29
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis.
Embo J., 41, 2022
7QIZ
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BU of 7qiz by Molmil
Specific features and methylation sites of a plant 80S ribosome
Descriptor: 1,4-DIAMINOBUTANE, 18S, 25S rRNA, ...
Authors:Cottilli, P, Itoh, Y, Amunts, A.
Deposit date:2021-12-16
Release date:2022-08-03
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.38 Å)
Cite:Cryo-EM structure and rRNA modification sites of a plant ribosome.
Plant Commun., 3, 2022
8VTU
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BU of 8vtu by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution
Descriptor: 1-cyclopropyl-7-[(4-{[3-({(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-14-[({3-[5-(methylcarbamoyl)pyridin-3-yl]prop-2-yn-1-yl}oxy)imino]-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl}oxy)-3-oxopropyl]amino}butyl)amino]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8VTV
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BU of 8vtv by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution
Descriptor: 1-cyclopropyl-7-{7-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]hept-1-yn-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8VTX
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BU of 8vtx by Molmil
Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution
Descriptor: 1-cyclopropyl-7-(4-{4-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]butyl}piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8VTW
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BU of 8vtw by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-cyclopropyl-7-(4-{4-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]butyl}piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
1SNT
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BU of 1snt by Molmil
Structure of the human cytosolic sialidase Neu2
Descriptor: Sialidase 2
Authors:Chavas, L.M.G, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Kato, R, Monti, E, Wakatsuki, S.
Deposit date:2004-03-12
Release date:2004-11-02
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION
J.Biol.Chem., 280, 2005
8W4Y
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BU of 8w4y by Molmil
Neutron structure of cellulase Cel6A from Phanerochaete chrysosporium at room temperature, low-D2O-solvent
Descriptor: Glucanase
Authors:Tachioka, M, Yamaguchi, S, Nakamura, A, Ishida, T, Kusaka, K, Yamada, T, Yano, N, Chatake, T, Tamada, T, Takeda, K, Niwa, S, Tanaka, H, Takahashi, S, Inaka, K, Furubayashi, N, Deguchi, S, Samejima, M, Igarashi, K.
Deposit date:2023-08-25
Release date:2025-03-12
Method:NEUTRON DIFFRACTION (1.4 Å), X-RAY DIFFRACTION
Cite:Deprotonated Arginine Controls a Putative Catalytic Base in Invert-ing Family 6 Glycoside Hydrolase
To Be Published
8W8U
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BU of 8w8u by Molmil
High-resolution X-ray structure of cellulase Cel6A from Phanerochaete chrysosporium at cryogenic temperature
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Glucanase
Authors:Tachioka, M, Yamaguchi, S, Nakamura, A, Ishida, T, Kusaka, K, Yamada, T, Yano, N, Chatake, T, Tamada, T, Takeda, K, Niwa, S, Tanaka, H, Takahashi, S, Inaka, K, Furubayashi, N, Deguchi, S, Samejima, M, Igarashi, K.
Deposit date:2023-09-04
Release date:2025-03-12
Method:X-RAY DIFFRACTION (0.8 Å)
Cite:Deprotonated Arginine Controls a Putative Catalytic Base in Invert-ing Family 6 Glycoside Hydrolase
To Be Published
8W4X
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BU of 8w4x by Molmil
Neutron structure of cellulase Cel6A from Phanerochaete chrysosporium at room temperature, Enzyme-Product complex
Descriptor: Glucanase, SODIUM ION, beta-D-glucopyranose, ...
Authors:Tachioka, M, Yamaguchi, S, Nakamura, A, Ishida, T, Kusaka, K, Yamada, T, Yano, N, Chatake, T, Tamada, T, Takeda, K, Niwa, S, Tanaka, H, Takahashi, S, Inaka, K, Furubayashi, N, Deguchi, S, Samejima, M, Igarashi, K.
Deposit date:2023-08-25
Release date:2025-03-12
Method:NEUTRON DIFFRACTION (1.4 Å), X-RAY DIFFRACTION
Cite:Deprotonated Arginine Controls a Putative Catalytic Base in Invert-ing Family 6 Glycoside Hydrolase
To Be Published
8WL5
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BU of 8wl5 by Molmil
X-ray structure of Enterobacter cloacae allose-binding protein in free form
Descriptor: 1,2-ETHANEDIOL, Allose ABC transporter
Authors:Kamitori, S.
Deposit date:2023-09-29
Release date:2023-10-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:X-ray structures of Enterobacter cloacae allose-binding protein in complexes with monosaccharides demonstrate its unique recognition mechanism for high affinity to allose.
Biochem.Biophys.Res.Commun., 682, 2023
1SO7
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BU of 1so7 by Molmil
Maltose-induced structure of the human cytolsolic sialidase Neu2
Descriptor: CHLORIDE ION, Sialidase 2
Authors:Chavas, L.M.G, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Kato, R, Monti, E, Wakatsuki, S.
Deposit date:2004-03-12
Release date:2004-11-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION
J.Biol.Chem., 280, 2005
7RQC
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BU of 7rqc by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S.
Deposit date:2021-08-06
Release date:2022-01-26
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
7RQB
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BU of 7rqb by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S.
Deposit date:2021-08-06
Release date:2022-01-26
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
7UG7
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BU of 7ug7 by Molmil
70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N.
Deposit date:2022-03-24
Release date:2022-05-18
Last modified:2025-03-19
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UNW
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BU of 7unw by Molmil
Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Basu, R.S, Sherman, M.B, Gagnon, M.G.
Deposit date:2022-04-11
Release date:2022-06-22
Last modified:2025-03-19
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
7UNV
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BU of 7unv by Molmil
Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Basu, R.S, Sherman, M.B, Gagnon, M.G.
Deposit date:2022-04-11
Release date:2022-06-22
Last modified:2025-03-19
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
7UNU
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BU of 7unu by Molmil
Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Basu, R.S, Sherman, M.B, Gagnon, M.G.
Deposit date:2022-04-11
Release date:2022-06-22
Last modified:2025-03-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
7UNR
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BU of 7unr by Molmil
Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Basu, R.S, Sherman, M.B, Gagnon, M.G.
Deposit date:2022-04-11
Release date:2022-06-22
Last modified:2025-03-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022

238582

數據於2025-07-09公開中

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