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5BTU
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BU of 5btu by Molmil
The structure of Diels-Alderase PyrI4 in the biosynthetic pathway of pyrroindomycins
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, PyrI4
Authors:Pan, L, Guo, Y, Liu, J.
Deposit date:2015-06-03
Release date:2016-02-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4
Cell Chem Biol, 23, 2016
2IHU
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BU of 2ihu by Molmil
Carboxyethylarginine synthase from Streptomyces clavuligerus: putative reaction intermediate complex
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 5-(2-{[HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-2-[(1Z)-1-HYDROXY-3-(PHOSPHONOOXY)PROP-1-EN-1-YL]-3-{[(4Z)-4-IMINO-2- METHYL-4,5-DIHYDROPYRIMIDIN-5-YL]METHYL}-4-METHYL-1,3-THIAZOL-3-IUM, Carboxyethylarginine synthase, ...
Authors:Caines, M.E, Schofield, C.J.
Deposit date:2006-09-27
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
Biochem.Biophys.Res.Commun., 385, 2009
2IHV
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BU of 2ihv by Molmil
Carboxyethylarginine synthase from Streptomyces clavuligerus: 5-guanidinovaleric acid complex
Descriptor: 5-{[AMINO(IMINO)METHYL]AMINO}PENTANOIC ACID, Carboxyethylarginine synthase, MAGNESIUM ION, ...
Authors:Caines, M.E, Schofield, C.J.
Deposit date:2006-09-27
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
Biochem.Biophys.Res.Commun., 385, 2009
2IHT
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BU of 2iht by Molmil
Carboxyethylarginine synthase from Streptomyces clavuligerus: SeMet structure
Descriptor: Carboxyethylarginine synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Caines, M.E, Schofield, C.J.
Deposit date:2006-09-27
Release date:2007-09-18
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
Biochem.Biophys.Res.Commun., 385, 2009
2KOS
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BU of 2kos by Molmil
NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase
Descriptor: Acyl carrier protein, S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate
Authors:Ploskon, E, Arthur, C, Crump, M.P.
Deposit date:2009-09-29
Release date:2010-08-18
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis
Chem.Biol., 17, 2010
2KOR
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BU of 2kor by Molmil
NMR solution structures of 2-octenoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase
Descriptor: Acyl carrier protein, S-[2-[3-[[(2S)-2-hydroxy-3,3-dimethyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (E)-oct-2-enethioate
Authors:Ploskon, E, Arthur, C.J, Crump, M.P.
Deposit date:2009-09-29
Release date:2010-08-18
Last modified:2024-11-13
Method:SOLUTION NMR
Cite:Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis
Chem.Biol., 17, 2010
3FPW
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BU of 3fpw by Molmil
Crystal Structure of HbpS with bound iron
Descriptor: Extracellular haem-binding protein, FE (III) ION, PHOSPHATE ION
Authors:Ortiz de Orue Lucana, D, Bogel, G, Zou, P, Groves, M.R.
Deposit date:2009-01-06
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The oligomeric assembly of the novel haem-degrading protein HbpS is essential for interaction with its cognate two-component sensor kinase
J.Mol.Biol., 386, 2009
3GDT
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BU of 3gdt by Molmil
Crystal structure of the D91N mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae complexed with 6-azauridine 5'-monophosphate
Descriptor: 6-AZA URIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase
Authors:Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C.
Deposit date:2009-02-24
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.
Biochemistry, 48, 2009
1OAD
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BU of 1oad by Molmil
Glucose isomerase from Streptomyces rubiginosus in P21212 crystal form
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Ramagopal, U.A, Dauter, M, Dauter, Z.
Deposit date:2003-01-08
Release date:2003-01-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Sad Manganese in Two Crystal Forms of Glucose Isomerase
Acta Crystallogr.,Sect.D, 59, 2003
1NQ4
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BU of 1nq4 by Molmil
Solution Structure of Oxytetracycline Acyl Carrier Protein
Descriptor: Oxytetracycline polyketide synthase acyl carrier protein
Authors:Findlow, S.C, Winsor, C, Simpson, T.J, Crosby, J, Crump, M.P.
Deposit date:2003-01-21
Release date:2003-11-04
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus
Biochemistry, 42, 2003
5I1U
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BU of 5i1u by Molmil
Crystal structure of germacradien-4-ol synthase from Streptomyces citricolor
Descriptor: Germacradien-4-ol synthase, SULFATE ION
Authors:Chen, M, Christianson, D.W.
Deposit date:2016-02-06
Release date:2016-03-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.
Biochemistry, 55, 2016
7VWK
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BU of 7vwk by Molmil
The product template domain of AviM
Descriptor: Polyketide synthase
Authors:Feng, Y, Yang, X, Zheng, J.
Deposit date:2021-11-10
Release date:2022-06-08
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases.
Commun Biol, 5, 2022
5IGJ
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BU of 5igj by Molmil
Macrolide 2'-phosphotransferase type I - complex with guanosine and clarithromycin
Descriptor: CLARITHROMYCIN, GUANOSINE, ISOPROPYL ALCOHOL, ...
Authors:Berghuis, A.M, Fong, D.H.
Deposit date:2016-02-28
Release date:2017-04-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.
Structure, 25, 2017
5IGP
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BU of 5igp by Molmil
Macrolide 2'-phosphotransferase type I - complex with GDP and erythromycin
Descriptor: ERYTHROMYCIN A, GUANOSINE-5'-DIPHOSPHATE, ISOPROPYL ALCOHOL, ...
Authors:Berghuis, A.M, Fong, D.H.
Deposit date:2016-02-28
Release date:2017-04-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.
Structure, 25, 2017
1PWG
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BU of 1pwg by Molmil
Covalent Penicilloyl Acyl Enzyme Complex Of The Streptomyces R61 DD-Peptidase With A Highly Specific Penicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase
Authors:Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.074 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
4LHK
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BU of 4lhk by Molmil
Structure of the N-terminal domain of the Lg-Flo1 adhesin (N-Lg-Flo1p) from the yeast Saccharomyces pastorianus, in complex with calcium and alpha-1,2-mannobiose
Descriptor: CALCIUM ION, Flocculin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose
Authors:Ielasi, F.S, Willaert, R.G.
Deposit date:2013-07-01
Release date:2014-09-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival.
MBio, 6, 2015
2NPU
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BU of 2npu by Molmil
The solution structure of the rapamycin-binding domain of mTOR (FRB)
Descriptor: FKBP12-rapamycin complex-associated protein
Authors:Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
3V7I
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BU of 3v7i by Molmil
Germicidin synthase (Gcs) from Streptomyces coelicolor, a type III polyketide synthase
Descriptor: Putative polyketide synthase
Authors:Akey, D.L, Smith, J.L, Geders, T.W.
Deposit date:2011-12-21
Release date:2012-04-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor.
J.Am.Chem.Soc., 134, 2012
4D7K
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BU of 4d7k by Molmil
Crystal structure of N,N-8-amino-8-demethyl-D-riboflavin dimethyltransferase (RosA) from Streptomyces davawensis
Descriptor: SAM-DEPENDENT METHYLTRANSFERASES
Authors:Uhl, M.K, Gruber, K.
Deposit date:2014-11-25
Release date:2016-01-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural and Kinetic Studies on Rosa, the Enzyme Catalysing the Methylation of 8-Demethyl-8-Amino-D-Riboflavin to the Antibiotic Roseoflavin
FEBS J., 283, 2016
3WUG
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BU of 3wug by Molmil
The mutant crystal structure of b-1,4-Xylanase (XynAS9_V43P/G44E) with xylobiose from Streptomyces sp. 9
Descriptor: Endo-1,4-beta-xylanase A, ZINC ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose
Authors:Chen, C.C, Han, X, Lv, P, Ko, T.P, Peng, W, Huang, C.H, Zheng, Y, Gao, J, Yang, Y.Y, Guo, R.T.
Deposit date:2014-04-23
Release date:2014-10-29
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability.
J.Biotechnol., 189C, 2014
3TL1
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BU of 3tl1 by Molmil
Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase
Descriptor: 6,7,9-trihydroxy-3-methyl-1H-benzo[g]isochromen-1-one, GLYCEROL, Polyketide cyclase
Authors:Lee, M.-Y, Ames, B.D, Zhang, W, Tang, Y, Tsai, S.-C.
Deposit date:2011-08-29
Release date:2012-04-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI.
Biochemistry, 51, 2012
3WUF
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BU of 3wuf by Molmil
The mutant crystal structure of b-1,4-Xylanase (XynAS9_V43P/G44E) from Streptomyces sp. 9
Descriptor: Endo-1,4-beta-xylanase A, ZINC ION
Authors:Chen, C.C, Han, X, Lv, P, Ko, T.P, Peng, W, Huang, C.H, Zheng, Y, Gao, J, Yang, Y.Y, Guo, R.T.
Deposit date:2014-04-23
Release date:2014-10-29
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability.
J.Biotechnol., 189C, 2014
3BTS
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BU of 3bts by Molmil
Crystal structure of a ternary complex of the transcriptional repressor Gal80p (Gal80S0 [G301R]) and the acidic activation domain of Gal4p (aa 854-874) from Saccharomyces cerevisiae with NAD
Descriptor: Galactose/lactose metabolism regulatory protein GAL80, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Regulatory protein GAL4
Authors:Kumar, P.R, Joshua-Tor, L.
Deposit date:2007-12-30
Release date:2008-03-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:NADP regulates the yeast GAL induction system.
Science, 319, 2008
2FSX
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BU of 2fsx by Molmil
Crystal structure of Rv0390 from M. tuberculosis
Descriptor: BROMIDE ION, COG0607: Rhodanese-related sulfurtransferase, SULFATE ION
Authors:Bursey, E.H, Radhakannan, T, Yu, M, Segelke, B.W, Lekin, T, Toppani, D, Chang, Y.-B, Kaviratne, T, Woodruff, T, Terwilliger, T.C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-01-23
Release date:2006-02-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Rv0390 from Mycobacterium tuberculosis
To be Published
3BTU
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BU of 3btu by Molmil
Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S2) [E351K]
Descriptor: Galactose/lactose metabolism regulatory protein GAL80
Authors:Kumar, P.R, Joshua-Tor, L.
Deposit date:2007-12-30
Release date:2008-03-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:NADP regulates the yeast GAL induction system.
Science, 319, 2008

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數據於2025-05-07公開中

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