3TL1

Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase

Summary for 3TL1

Entry DOI	10.2210/pdb3tl1/pdb
Descriptor	Polyketide cyclase, 6,7,9-trihydroxy-3-methyl-1H-benzo[g]isochromen-1-one, GLYCEROL, ... (4 entities in total)
Functional Keywords	helix-grip fold, polyketide c9-c14 aromatase/cyclase, linear poly-beta-ketone intermediate, biosynthetic protein
Biological source	Streptomyces coelicolor
Total number of polymer chains	2
Total formula weight	37225.41
Authors	Lee, M.-Y.,Ames, B.D.,Zhang, W.,Tang, Y.,Tsai, S.-C. (deposition date: 2011-08-29, release date: 2012-04-04, Last modification date: 2024-02-28)
Primary citation	Lee, M.Y.,Ames, B.D.,Tsai, S.C. Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI. Biochemistry, 51:3079-3091, 2012 Cited by PubMed: 22432862 DOI: 10.1021/bi201705q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation