3GDT

Crystal structure of the D91N mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae complexed with 6-azauridine 5'-monophosphate

Summary for 3GDT

Entry DOI	10.2210/pdb3gdt/pdb
Related	1DQW 3GDK 3GDL 3GDM 3GDR
Descriptor	Orotidine 5'-phosphate decarboxylase, 6-AZA URIDINE 5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	orotidine 5'-monophosphate decarboxylase, d91n mutant, 6-azauridine 5'-monophosphate, decarboxylase, lyase, phosphoprotein, pyrimidine biosynthesis, ubl conjugation
Biological source	Saccharomyces cerevisiae (yeast)
Total number of polymer chains	4
Total formula weight	118414.86
Authors	Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2009-02-24, release date: 2009-06-23, Last modification date: 2023-09-06)
Primary citation	Chan, K.K.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Imker, H.J.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48:5518-5531, 2009 Cited by PubMed: 19435314 DOI: 10.1021/bi900623r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation