7CZ9
 
 | | Crystal structure of multidrug efflux transporter OqxB from Klebsiella pneumoniae | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter, GLYCEROL, ... | | Authors: | Murakami, S, Okada, U, Yamashita, E. | | Deposit date: | 2020-09-07 | | Release date: | 2021-09-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.
Nat Commun, 12, 2021
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3K0I
 | | Crystal structure of Cu(I)CusA | | Descriptor: | COPPER (I) ION, Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-09-24 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.116 Å) | | Cite: | Crystal structure of CusA
To be Published
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3K07
 | | Crystal structure of CusA | | Descriptor: | Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-09-24 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.521 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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9BFM
 | | Cryo-EM co-structure of AcrB with the EPM35 efflux pump inhibitor | | Descriptor: | (2S)-1-(3,4-dichlorophenoxy)-3-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}piperidin-1-yl)propan-2-ol, Multidrug efflux pump subunit AcrB | | Authors: | Su, C.C. | | Deposit date: | 2024-04-18 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
mBio, 14, 2023
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9BFT
 | | Cryo-EM co-structure of AcrB with CU244 | | Descriptor: | (2S)-1-{[(1R,5R)-3-azabicyclo[3.1.0]hexan-6-yl]amino}-3-(3,5-dichlorophenoxy)propan-2-ol, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Multidrug efflux pump subunit AcrB | | Authors: | Su, C.C. | | Deposit date: | 2024-04-18 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
mBio, 14, 2023
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9BFH
 | | Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor | | Descriptor: | (2S)-1-[(3R)-3-aminopyrrolidin-1-yl]-3-(3,4-dichlorophenoxy)propan-2-ol, Multidrug efflux pump subunit AcrB | | Authors: | Su, C.C. | | Deposit date: | 2024-04-17 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
mBio, 14, 2023
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9BFN
 | | Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor | | Descriptor: | (2R)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Multidrug efflux pump subunit AcrB | | Authors: | Su, C.C. | | Deposit date: | 2024-04-18 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
mBio, 14, 2023
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8F3E
 | | Trimer of aminoglycoside efflux pump AcrD | | Descriptor: | Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2022-11-10 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
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3AOB
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3AOC
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3AOA
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7B8S
 | | Fusidic acid bound structure of bacterial efflux pump. | | Descriptor: | DARPin, FUSIDIC ACID, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | Authors: | Wilhelm, J, Sjuts, H, Pos, K.M. | | Deposit date: | 2020-12-13 | | Release date: | 2021-10-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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7B8T
 | | Levofloxacin bound structure of bacterial efflux pump. | | Descriptor: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | Authors: | Wilhelm, J, Sjuts, H, Pos, K.M. | | Deposit date: | 2020-12-13 | | Release date: | 2021-10-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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7B8R
 | | Doxycycline bound structure of bacterial efflux pump. | | Descriptor: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Wilhelm, J, Sjuts, H, Pos, K.M. | | Deposit date: | 2020-12-13 | | Release date: | 2021-10-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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6VKT
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6VKS
 | | Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin | | Descriptor: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE | | Authors: | Moseng, M.A, Lyu, M. | | Deposit date: | 2020-01-22 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
Mbio, 11, 2020
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3KSO
 | | Structure and Mechanism of the Heavy Metal Transporter CusA | | Descriptor: | Cation efflux system protein cusA, SILVER ION | | Authors: | Su, C.-C. | | Deposit date: | 2009-11-23 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.367 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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3KSS
 | | Structure and Mechanism of the Heavy Metal Transporter CusA | | Descriptor: | COPPER (I) ION, Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-11-23 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.88 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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2GIF
 | | Asymmetric structure of trimeric AcrB from Escherichia coli | | Descriptor: | Acriflavine resistance protein B, CITRATE ANION | | Authors: | Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M. | | Deposit date: | 2006-03-28 | | Release date: | 2006-09-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism.
Science, 313, 2006
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3AOD
 | | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket | | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, RIFAMPICIN | | Authors: | Nakashima, R, Sakurai, K, Yamaguchi, A. | | Deposit date: | 2010-09-23 | | Release date: | 2011-11-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nature, 480, 2011
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2DR6
 | | Crystal structure of a multidrug transporter reveal a functionally rotating mechanism | | Descriptor: | ACRB, DOXORUBICIN | | Authors: | Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature, 443, 2006
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2DHH
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1OY8
 | | Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | | Descriptor: | Acriflavine resistance protein B, RHODAMINE 6G | | Authors: | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | Deposit date: | 2003-04-03 | | Release date: | 2003-05-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.63 Å) | | Cite: | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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1OY9
 | | Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | | Descriptor: | Acriflavine resistance protein B, ETHIDIUM | | Authors: | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | Deposit date: | 2003-04-03 | | Release date: | 2003-05-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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1OYD
 | | Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump | | Descriptor: | Acriflavine resistance protein B, DEQUALINIUM | | Authors: | Yu, E.W, MeDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | Deposit date: | 2003-04-03 | | Release date: | 2003-05-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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