7RR7
 
 | | Multidrug efflux pump subunit AcrB | | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | Deposit date: | 2021-08-09 | | Release date: | 2022-08-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Multidrug efflux pump subunit AcrB
To Be Published
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7RR8
 | | Multidrug efflux pump subunit AcrB | | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | Deposit date: | 2021-08-09 | | Release date: | 2022-08-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Multidrug efflux pump subunit AcrB
To Be Published
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7RR6
 | | Multidrug efflux pump subunit AcrB | | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | Deposit date: | 2021-08-09 | | Release date: | 2022-08-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Multidrug efflux pump subunit AcrB
To Be Published
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6VKT
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7CZ9
 | | Crystal structure of multidrug efflux transporter OqxB from Klebsiella pneumoniae | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter, GLYCEROL, ... | | Authors: | Murakami, S, Okada, U, Yamashita, E. | | Deposit date: | 2020-09-07 | | Release date: | 2021-09-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.
Nat Commun, 12, 2021
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3AOA
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3AOB
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3AOC
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3KSS
 | | Structure and Mechanism of the Heavy Metal Transporter CusA | | Descriptor: | COPPER (I) ION, Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-11-23 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.88 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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8GJL
 | | multi-drug efflux pump RE-CmeB bound with Ciprofloxacin | | Descriptor: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2023-03-16 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GJJ
 | | Multi-drug efflux pump RE-CmeB Apo form | | Descriptor: | Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2023-03-15 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GK4
 | | Multi-drug efflux pump RE-CmeB bound with Chloramphenicol | | Descriptor: | CHLORAMPHENICOL, Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2023-03-17 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GK0
 | | Multi-drug efflux pump RE-CmeB bound with Erythromycin | | Descriptor: | ERYTHROMYCIN A, Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2023-03-16 | | Release date: | 2023-06-07 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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3K0I
 | | Crystal structure of Cu(I)CusA | | Descriptor: | COPPER (I) ION, Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-09-24 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.116 Å) | | Cite: | Crystal structure of CusA
To be Published
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3D9B
 | | Symmetric structure of E. coli AcrB | | Descriptor: | Acriflavine resistance protein B, NICKEL (II) ION | | Authors: | Veesler, D, Blangy, S, Cambillau, C, Sciara, G. | | Deposit date: | 2008-05-27 | | Release date: | 2008-07-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | There is a baby in the bath water: AcrB contamination is a major problem in membrane-protein crystallization.
Acta Crystallogr.,Sect.F, 64, 2008
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3K07
 | | Crystal structure of CusA | | Descriptor: | Cation efflux system protein cusA | | Authors: | Su, C.-C. | | Deposit date: | 2009-09-24 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.521 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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8GJK
 | | Multi-drug efflux pump RE-CmeB bound with ampicillin | | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2023-03-16 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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3KSO
 | | Structure and Mechanism of the Heavy Metal Transporter CusA | | Descriptor: | Cation efflux system protein cusA, SILVER ION | | Authors: | Su, C.-C. | | Deposit date: | 2009-11-23 | | Release date: | 2010-09-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.367 Å) | | Cite: | Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
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3AOD
 | | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket | | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, RIFAMPICIN | | Authors: | Nakashima, R, Sakurai, K, Yamaguchi, A. | | Deposit date: | 2010-09-23 | | Release date: | 2011-11-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nature, 480, 2011
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6Q4O
 | | Fusidic acid bound AcrB_I27A | | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPIN, DECANE, ... | | Authors: | Tam, H.K, Pos, K.M. | | Deposit date: | 2018-12-06 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
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4CDI
 | | Crystal structure of AcrB-AcrZ complex | | Descriptor: | ACRIFLAVINE RESISTANCE PROTEIN B, PREDICTED PROTEIN | | Authors: | Du, D, James, N, Klimont, E, Luisi, B.F. | | Deposit date: | 2013-10-31 | | Release date: | 2014-04-30 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Structure of the Acrab-Tolc Multidrug Efflux Pump.
Nature, 509, 2014
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6Q4N
 | | Fusidic acid bound AcrB_V340A | | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPin, DECANE, ... | | Authors: | Tam, H.K, Pos, K.M. | | Deposit date: | 2018-12-06 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
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8FFK
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8FFS
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8F4N
 | | Dimer of aminoglycoside efflux pump AcrD | | Descriptor: | Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2022-11-11 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
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