7B8R

Doxycycline bound structure of bacterial efflux pump.

Summary for 7B8R

• Entry DOI: 10.2210/pdb7b8r/pdb
• Descriptor: Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, DARPin, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: rnd transporter, multidrug resistance, efflux pump, antibiotics, transport protein
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 6
• Total formula weight: 254669.31

Authors

Wilhelm, J.,Sjuts, H.,Pos, K.M. (deposition date: 2020-12-13, release date: 2021-10-20, Last modification date: 2024-01-31)

• Primary citation: Ornik-Cha, A.,Wilhelm, J.,Kobylka, J.,Sjuts, H.,Vargiu, A.V.,Malloci, G.,Reitz, J.,Seybert, A.,Frangakis, A.S.,Pos, K.M.; Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.; Nat Commun, 12:6919-6919, 2021; PubMed: 34824229; DOI: 10.1038/s41467-021-27146-2

Experimental method

X-RAY DIFFRACTION (2.1 Å)