2GIF

Asymmetric structure of trimeric AcrB from Escherichia coli

Summary for 2GIF

• Entry DOI: 10.2210/pdb2gif/pdb
• Related: 1IWG
• Descriptor: Acriflavine resistance protein B, CITRATE ANION (2 entities in total)
• Functional Keywords: membrane protein, secondary transport, rnd, antibiotic resistance, drug-efflux pump, alternating site mechanism, membrane protein-transport protein complex, membrane protein/transport protein
• Biological source: Escherichia coli
• Cellular location: Cell inner membrane ; Multi- pass membrane protein : P31224
• Total number of polymer chains: 3
• Total formula weight: 344587.07

Authors

Seeger, M.A.,Schiefner, A.,Eicher, T.,Verrey, F.,Diederichs, K.,Pos, K.M. (deposition date: 2006-03-28, release date: 2006-09-12, Last modification date: 2023-08-30)

• Primary citation: Seeger, M.A.,Schiefner, A.,Eicher, T.,Verrey, F.,Diederichs, K.,Pos, K.M.; Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism.; Science, 313:1295-1298, 2006; PubMed: 16946072; DOI: 10.1126/science.1131542

Experimental method

X-RAY DIFFRACTION (2.9 Å)