Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GIF

Asymmetric structure of trimeric AcrB from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015567	molecular_function	alkane transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0015895	biological_process	alkane transport
C	0015908	biological_process	fatty acid transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC B 1058

Chain	Residue
A	ILE763
B	LYS55
B	GLN58
B	ASP59
B	GLY691
B	HIS692
B	LEU816

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FLC A 1058

Chain	Residue
A	HIS692
A	LEU816
C	ILE763
A	GLN58
A	ASP59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1932
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	348
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=8"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=9"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=10"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=11"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=12"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)