9BFN

Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor

This is a non-PDB format compatible entry.

Summary for 9BFN

• Entry DOI: 10.2210/pdb9bfn/pdb
• EMDB information: 44501
• Descriptor: Multidrug efflux pump subunit AcrB, 1,2-Distearoyl-sn-glycerophosphoethanolamine, (2R)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol, ... (4 entities in total)
• Functional Keywords: acrb multidrug efflux pump, translocase
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 3
• Total formula weight: 342810.01

Authors

Su, C.C. (deposition date: 2024-04-18, release date: 2024-05-08)

• Primary citation: Allgood, S.C.,Su, C.C.,Crooks, A.L.,Meyer, C.T.,Zhou, B.,Betterton, M.D.,Barbachyn, M.R.,Yu, E.W.,Detweiler, C.S.; Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.; mBio, 14:e0249223-, 2023; PubMed: 37921493; DOI: 10.1073/pnas.1901346116

Experimental method

ELECTRON MICROSCOPY (2.71 Å)