6VKS

Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin

Summary for 6VKS

Entry DOI	10.2210/pdb6vks/pdb
EMDB information	21228
Descriptor	Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE, (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (3 entities in total)
Functional Keywords	drug, efflux, pump, mtrd, membrane protein, ampicillin
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	3
Total formula weight	348957.37
Authors	Moseng, M.A.,Lyu, M. (deposition date: 2020-01-22, release date: 2020-07-01, Last modification date: 2024-03-06)
Primary citation	Lyu, M.,Moseng, M.A.,Reimche, J.L.,Holley, C.L.,Dhulipala, V.,Su, C.C.,Shafer, W.M.,Yu, E.W. Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance. Mbio, 11:-, 2020 Cited by PubMed: 32457251 DOI: 10.1128/mBio.00996-20 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.02 Å)

Structure validation