6VKS
Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PTY A 1101 |
| Chain | Residue |
| A | ARG8 |
| A | PHE18 |
| B | ILE441 |
| B | LEU888 |
| B | PTY1101 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PTY A 1102 |
| Chain | Residue |
| A | TRP13 |
| A | ILE17 |
| B | PTY1103 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PTY A 1103 |
| Chain | Residue |
| A | PHE1040 |
| A | THR1043 |
| C | PTY1104 |
| A | TRP892 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PTY B 1101 |
| Chain | Residue |
| A | PTY1101 |
| B | MET1 |
| B | PHE5 |
| B | SER437 |
| B | PTY1102 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PTY B 1102 |
| Chain | Residue |
| B | PHE11 |
| B | PTY1101 |
| C | ALA887 |
| C | LEU888 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PTY B 1103 |
| Chain | Residue |
| A | PTY1102 |
| B | PHE882 |
| B | TRP892 |
| B | LEU896 |
| B | LEU899 |
| B | PHE1040 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PTY B 1104 |
| Chain | Residue |
| B | ALA21 |
| B | ALA22 |
| B | ILE24 |
| B | PHE25 |
| C | MET456 |
| C | ALA872 |
| C | ALA875 |
| C | PTY1103 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PTY B 1105 |
| Chain | Residue |
| B | ILE27 |
| B | ASN296 |
| B | ILE335 |
| B | LEU374 |
| B | PHE378 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue AIX B 1106 |
| Chain | Residue |
| B | PHE136 |
| B | PHE176 |
| B | VAL607 |
| B | PHE610 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue PTY C 1101 |
| Chain | Residue |
| A | GLY438 |
| A | LEU888 |
| A | MET1049 |
| C | PHE4 |
| C | ARG8 |
| C | PHE11 |
| C | PHE18 |
| C | PTY1102 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue PTY C 1102 |
| Chain | Residue |
| C | LYS3 |
| C | PHE4 |
| C | PTY1101 |
| C | PTY1107 |
| C | PTY1108 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue PTY C 1104 |
| Chain | Residue |
| A | PTY1103 |
| C | ILE17 |
| C | PTY1105 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue PTY C 1105 |
| Chain | Residue |
| C | TRP13 |
| C | ARG361 |
| C | MET494 |
| C | PTY1104 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue PTY C 1106 |
| Chain | Residue |
| C | ILE27 |
| C | ILE343 |
| C | PTY1109 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue PTY C 1107 |
| Chain | Residue |
| C | MET1 |
| C | PHE4 |
| C | PHE5 |
| C | PHE481 |
| C | PTY1102 |
| C | PTY1108 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue PTY C 1108 |
| Chain | Residue |
| C | PTY1102 |
| C | PTY1107 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PTY C 1109 |
| Chain | Residue |
| C | ILE339 |
| C | LEU374 |
| C | MET393 |
| C | PTY1106 |
| site_id | AD9 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide PTY C 1103 and PHE C 1040 |
| Chain | Residue |
| B | PTY1104 |
| C | VAL879 |
| C | PHE882 |
| C | SER891 |
| C | TRP892 |
| C | SER893 |
| C | LEU896 |
| C | VAL1036 |
| C | ARG1037 |
| C | LYS1038 |
| C | PHE1039 |
| C | LYS1041 |
| C | GLU1042 |
