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1TOO	Interleukin 1B Mutant F146W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-14 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TP0	Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan. Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-15 Release date: 2005-02-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Capsar, D.L. Deposit date: 2004-06-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWM	Interleukin-1 Beta Mutant F146Y Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Capsar, D.L. Deposit date: 2004-07-01 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1T4Q	Interleukin 1 beta F101W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-04-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
4X39	Gallus interleukin-1 beta mutant - T117A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Gallus interleukin-1 beta mutant - T117A To Be Published
4X38	Gallus interleukin-1 beta mutant - E118A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Gallus interleukin-1 beta mutant - E118A To Be Published
4XFU	Structure of IL-18 SER Mutant V Descriptor: Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFS	Structure of IL-18 SER Mutant I Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-28 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4X37	Gallus interleukin-1 mutant - E118K Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T, Cheng, T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Gallus interleukin-1 mutant - E118K To Be Published
4XFT	Structure of IL-18 SER Mutant III Descriptor: DIMETHYL SULFOXIDE, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4GAI	Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra Descriptor: EBI-005 Authors: Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. Deposit date: 2012-07-25 Release date: 2013-02-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
2IRT	INITIAL CRYSTALLOGRAPHIC ANALYSES OF A RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN Descriptor: INTERLEUKIN-1 RECEPTOR ANTAGONIST Authors: Finzel, B.C, Clancy, L.L, Einspahr, H.M. Deposit date: 1994-07-13 Release date: 1994-10-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Initial crystallographic analysis of a recombinant human interleukin-1 receptor antagonist protein. Acta Crystallogr.,Sect.D, 50, 1994
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule Descriptor: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... Authors: Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. Deposit date: 2012-10-12 Release date: 2013-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
2ILA	STRUCTURE OF INTERLEUKIN 1ALPHA AT 2.7-ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-1 ALPHA Authors: Graves, B.J, Hatada, M.H. Deposit date: 1991-05-01 Release date: 1992-10-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of interleukin 1 alpha at 2.7-A resolution. Biochemistry, 29, 1990
4IZE	Crystal Structure of IL-36gamma Descriptor: Interleukin-36 gamma Authors: Guenther, S, Sundberg, E.J. Deposit date: 2013-01-29 Release date: 2014-06-25 Last modified: 2014-07-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014
4G6J	Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.03 Å) Cite: One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425, 2013
2I1B	CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-1 BETA Authors: Priestle, J.P, Schaer, H.-P, Gruetter, M.G. Deposit date: 1990-01-02 Release date: 1990-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallographic refinement of interleukin 1 beta at 2.0 A resolution. Proc.Natl.Acad.Sci.USA, 86, 1989
4I1B	FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Raag, R, Svensson, L.A, Masui, Y, Hirai, Y. Deposit date: 1990-03-27 Release date: 1990-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins, 12, 1992
2KH2	Solution structure of a scFv-IL-1B complex Descriptor: Interleukin-1 beta, scFv Authors: Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. Deposit date: 2009-03-23 Release date: 2009-09-08 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development. J.Biol.Chem., 284, 2009
4G6M	Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab Descriptor: Interleukin-1 beta, heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab J.Mol.Biol., 425, 2013
2KKI	Solution structure of human Interleukin 1a Descriptor: Interleukin-1 alpha Authors: Mohan, S.K, Chang, H.-K, Yu, C. Deposit date: 2009-06-24 Release date: 2010-06-30 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: 1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha Biomol.Nmr Assign., 4, 2010
2MIB	THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-1 BETA Authors: Priestle, J.P, Van Oostrum, J, Schmitz, A, Gruetter, M.G. Deposit date: 1993-12-06 Release date: 1994-01-31 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.84 Å) Cite: The structure of murine interleukin-1 beta at 2.8 A resolution. J.Struct.Biol., 107, 1991
5R7W	PanDDA analysis group deposition of ground-state model of INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-02 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.27 Å) Cite: PanDDA analysis group deposition of ground-state model To Be Published
5R86	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z943693514 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-(4-hydroxyphenyl)-2-methoxy-ethanamide Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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