4I1B

FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE

Summary for 4I1B

• Entry DOI: 10.2210/pdb4i1b/pdb
• Descriptor: INTERLEUKIN-1 BETA (2 entities in total)
• Functional Keywords: cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P01584
• Total number of polymer chains: 1
• Total formula weight: 17395.83

Authors

Veerapandian, B.,Poulos, T.L.,Gilliland, G.L.,Raag, R.,Svensson, L.A.,Masui, Y.,Hirai, Y. (deposition date: 1990-03-27, release date: 1990-04-15, Last modification date: 2024-02-28)

Primary citation

Veerapandian, B.,Gilliland, G.L.,Raag, R.,Svensson, A.L.,Masui, Y.,Hirai, Y.,Poulos, T.L.
Functional implications of interleukin-1 beta based on the three-dimensional structure.
Proteins, 12:10-23, 1992

PubMed Abstract: The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the three-dimensional structure, together with results from site-directed mutagenesis and biochemical and immunological studies, suggest that the core of the beta-barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL-1 interacts with its receptor.

PubMed: 1553379
DOI: 10.1002/prot.340120103

Experimental method

X-RAY DIFFRACTION (2 Å)