4GAI

Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra

Summary for 4GAI

• Entry DOI: 10.2210/pdb4gai/pdb
• Related: 4GAF
• Descriptor: EBI-005 (2 entities in total)
• Functional Keywords: il-1beta, il-1ra, il-1r1, il-1 signaling, beta-trefoil, signaling protein
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 35438.66

Authors

Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.,Thomas, C.,Garcia, K.C.,Furfine, E.S.,Barnes, T.M. (deposition date: 2012-07-25, release date: 2013-02-20, Last modification date: 2024-02-28)

• Primary citation: Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.M.,Schirmer, E.,Golden, K.,Thomas, C.,Garcia, K.C.,Zarbis-Papastoitsis, G.,Furfine, E.S.,Barnes, T.M.; Design of a superior cytokine antagonist for topical ophthalmic use.; Proc.Natl.Acad.Sci.USA, 110:3913-3918, 2013; PubMed: 23431173; DOI: 10.1073/pnas.1217996110

Experimental method

X-RAY DIFFRACTION (1.49 Å)