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8HLZ
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F8-A22-E4 complex of MPXV in hexameric form
Descriptor: DNA polymerase, DNA polymerase processivity factor component A20, E4R
Authors:Li, Y.N, Shen, Y.P, Hu, Z.W, Yan, R.H.
Deposit date:2022-12-02
Release date:2023-05-31
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant.
Sci Adv, 9, 2023
8HG1
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BU of 8hg1 by Molmil
The structure of MPXV polymerase holoenzyme in replicating state
Descriptor: DNA (25-MER), DNA (38-MER), DNA polymerase, ...
Authors:Peng, Q, Xie, Y.F, Kuai, L, Wang, H, Qi, J.X, Gao, F, Shi, Y.
Deposit date:2022-11-13
Release date:2022-12-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of monkeypox virus DNA polymerase holoenzyme.
Science, 379, 2023
8HDZ
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BU of 8hdz by Molmil
Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form
Descriptor: A22 DNA replication processivity factor, E4 uracil-DNA glycosylase, F8 DNA polymerase
Authors:Xu, Y, Wu, Y, Zhang, Y, Fan, R, Yang, Y, Li, D, Yang, B, Zhang, Z, Dong, C.
Deposit date:2022-11-07
Release date:2023-11-15
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex.
Cell Res., 33, 2023
8B9B
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BU of 8b9b by Molmil
S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand.
Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ...
Authors:Jones, M.L, Yeeles, J.T.P.
Deposit date:2022-10-05
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B9A
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BU of 8b9a by Molmil
S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand.
Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ...
Authors:Jones, M.L, Yeeles, J.T.P.
Deposit date:2022-10-05
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B9C
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BU of 8b9c by Molmil
S. cerevisiae pol alpha - replisome complex
Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ...
Authors:Jones, M.L, Yeeles, J.T.P.
Deposit date:2022-10-05
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B9D
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BU of 8b9d by Molmil
Human replisome bound by Pol Alpha
Descriptor: Cell division control protein 45 homolog, Claspin, DNA Molecule, ...
Authors:Jones, M.L, Yeeles, J.T.P.
Deposit date:2022-10-05
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B79
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BU of 8b79 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B7E
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BU of 8b7e by Molmil
The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B77
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BU of 8b77 by Molmil
The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B76
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BU of 8b76 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-28
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B6K
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BU of 8b6k by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-27
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B67
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BU of 8b67 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-26
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8D96
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BU of 8d96 by Molmil
Human DNA polymerase alpha/primase elongation complex I bound to primer/template
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ...
Authors:He, Q, Baranovskiy, A, Lim, C, Tahirov, T.
Deposit date:2022-06-09
Release date:2023-04-19
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
8D9D
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BU of 8d9d by Molmil
Human DNA polymerase-alpha/primase elongation complex II bound to primer/template
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ...
Authors:He, Q, Baranovskiy, A, Lim, C, Tahirov, T.
Deposit date:2022-06-09
Release date:2023-04-19
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
8D0B
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BU of 8d0b by Molmil
Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template
Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
Authors:He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C.
Deposit date:2022-05-26
Release date:2022-06-22
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
8D0K
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BU of 8d0k by Molmil
Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC
Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
Authors:He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C.
Deposit date:2022-05-26
Release date:2022-06-22
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.27 Å)
Cite:Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
7UY7
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BU of 7uy7 by Molmil
Tetrahymena CST with Polymerase alpha-Primase
Descriptor: DNA polymerase, Telomerase associated protein p50, Telomerase-associated protein of 19 kDa, ...
Authors:He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
Deposit date:2022-05-06
Release date:2022-07-13
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
7UY8
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BU of 7uy8 by Molmil
Tetrahymena Polymerase alpha-Primase
Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
Authors:He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
Deposit date:2022-05-06
Release date:2022-07-13
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
7U5C
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BU of 7u5c by Molmil
Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state
Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
Authors:Cai, S.W, Zinder, J.C, Svetlov, V, Bush, M.W, Nudler, E, Walz, T, de Lange, T.
Deposit date:2022-03-02
Release date:2022-05-18
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM structure of the human CST-Pol alpha /primase complex in a recruitment state.
Nat.Struct.Mol.Biol., 29, 2022
7Z13
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BU of 7z13 by Molmil
S. cerevisiae CMGE dimer nucleating origin DNA melting
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
Authors:Lewis, J.S, Sousa, J.S, Costa, A.
Deposit date:2022-02-24
Release date:2022-06-15
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022
7R3X
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BU of 7r3x by Molmil
The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ...
Authors:Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
Deposit date:2022-02-08
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
7R3Y
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BU of 7r3y by Molmil
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA Primer, ...
Authors:Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
Deposit date:2022-02-08
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
7TQW
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BU of 7tqw by Molmil
Kod RSGA incorporating PMT, n+2
Descriptor: DNA polymerase, Primer, Template
Authors:Hajjar, M, Chim, N, Chaput, J.C.
Deposit date:2022-01-27
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7QHS
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BU of 7qhs by Molmil
S. cerevisiae CMGE nucleating origin DNA melting
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
Authors:Lewis, J.S, Sousa, J.S, Costa, A.
Deposit date:2021-12-14
Release date:2022-06-15
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022

221051

數據於2024-06-12公開中

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