7R3X

The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide

Summary for 7R3X

Entry DOI	10.2210/pdb7r3x/pdb
Descriptor	DNA polymerase epsilon catalytic subunit A, DNA Primer, DNA Template, ... (7 entities in total)
Functional Keywords	protein-dna complex, dna binding protein
Biological source	Saccharomyces cerevisiae (baker's yeast) More
Total number of polymer chains	3
Total formula weight	145408.75
Authors	Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Johansson, E.,Shcherbakova, P.V. (deposition date: 2022-02-08, release date: 2022-07-27, Last modification date: 2024-01-31)
Primary citation	Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Moore, E.A.,Johansson, E.,Shcherbakova, P.V. Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50:8023-8040, 2022 Cited by PubMed: 35822874 DOI: 10.1093/nar/gkac602 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation