3S3K
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4Y14
| Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... | Authors: | Choy, M.S, Connors, C, Page, R, Peti, W. | Deposit date: | 2015-02-06 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
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4YAA
| YopH W354Y Yersinia enterocolitica PTPase apo form | Descriptor: | ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-02-17 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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3SR9
| Crystal structure of mouse PTPsigma | Descriptor: | Receptor-type tyrosine-protein phosphatase S | Authors: | Wang, J, Hou, L, Li, J, Ding, J. | Deposit date: | 2011-07-07 | Release date: | 2012-05-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma Acta Biochim.Biophys.Sin., 43, 2011
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4J51
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3SME
| Structure of PTP1B inactivated by H2O2/bicarbonate | Descriptor: | MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Tanner, J.J, Singh, H. | Deposit date: | 2011-06-27 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133, 2011
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4ZI4
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3I7Z
| Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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4Z6B
| YopH W354H Yersinia enterocolitica PTPase in the apo form | Descriptor: | ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase YopH | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-04-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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3S3E
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3I80
| Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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4ZN5
| YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site | Descriptor: | ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ... | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-05-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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4ZRT
| PTP1BC215S bound to Nephrin peptide substrate | Descriptor: | CHLORIDE ION, GLY-PRO-LEU-PTR-ASP-GLU, GLYCEROL, ... | Authors: | Selner, N.G, Bell, C.E, Pei, D. | Deposit date: | 2015-05-12 | Release date: | 2015-06-24 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry, 53, 2014
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4ICZ
| HER2 1221/1222 phosphorylation regulated by PTPN9 | Descriptor: | HER2, Tyrosine-protein phosphatase non-receptor type 9 | Authors: | Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P. | Deposit date: | 2012-12-11 | Release date: | 2013-12-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published
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4IKC
| Crystal Structure of catalytic domain of PTPRQ | Descriptor: | CHLORIDE ION, Phosphotidylinositol phosphatase PTPRQ, SULFATE ION | Authors: | Yu, K.R, Ryu, S.E, Kim, S.J. | Deposit date: | 2012-12-26 | Release date: | 2013-07-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates Acta Crystallogr.,Sect.D, 69, 2013
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3I36
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4I8N
| CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID | Descriptor: | Tyrosine-protein phosphatase non-receptor type 1, [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid | Authors: | Reddy, S.M.V.V.V, Rao, K.N, Subramanya, H. | Deposit date: | 2012-12-03 | Release date: | 2012-12-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein Pept.Lett., 21, 2014
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3U96
| Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS | Descriptor: | N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, SULFATE ION, Tyrosine-protein phosphatase yopH | Authors: | Ho, M.C, Ke, S. | Deposit date: | 2011-10-17 | Release date: | 2012-08-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination. J.Phys.Chem.B, 116, 2012
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6CWU
| Protein Tyrosine Phosphatase 1B F135Y mutant | Descriptor: | MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Hjortness, M, Zwart, P, Sankaran, B, Fox, J.M. | Deposit date: | 2018-03-31 | Release date: | 2018-10-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
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6D4F
| Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D) | Descriptor: | PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon | Authors: | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | Deposit date: | 2018-04-18 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.909 Å) | Cite: | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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6D4D
| Crystal structure of the PTP epsilon D1 domain | Descriptor: | Receptor-type tyrosine-protein phosphatase epsilon | Authors: | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | Deposit date: | 2018-04-18 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.765 Å) | Cite: | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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6DT6
| Crystal Structure of the YopH PTP1B Chimera 3 PTPase bound to vanadate | Descriptor: | Targeted effector protein, VANADATE ION | Authors: | Morales, Y, Johnson, S.J, Hengge, A.C. | Deposit date: | 2018-06-15 | Release date: | 2018-08-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
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6DRB
| Crystal Structure of the YopH PTP1B WPD loop Chimera 3 PTPase bound to tungstate | Descriptor: | TUNGSTATE(VI)ION, Targeted effector protein | Authors: | Morales, Y, Johnson, S.J, Hengge, A.C. | Deposit date: | 2018-06-11 | Release date: | 2018-08-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.745 Å) | Cite: | A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
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2JJD
| Protein Tyrosine Phosphatase, Receptor Type, E isoform | Descriptor: | CHLORIDE ION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON | Authors: | Elkins, J.M, Ugochukwu, E, Alfano, I, Barr, A.J, Bunkoczi, G, King, O.N.F, Filippakopoulos, P, Savitsky, P, Salah, E, Pike, A, Johansson, C, Das, S, Burgess-Brown, N.A, Gileadi, O, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S. | Deposit date: | 2008-03-31 | Release date: | 2008-04-08 | Last modified: | 2012-06-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2NLK
| Crystal structure of D1 and D2 catalytic domains of human Protein Tyrosine Phosphatase Gamma (D1+D2 PTPRG) | Descriptor: | Protein tyrosine phosphatase, receptor type, G variant (Fragment) | Authors: | Filippakopoulos, P, Gileadi, O, Johansson, C, Ugochukwu, E, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-10-20 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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