3SME
Structure of PTP1B inactivated by H2O2/bicarbonate
Summary for 3SME
Entry DOI | 10.2210/pdb3sme/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, MAGNESIUM ION (3 entities in total) |
Functional Keywords | hydrolase, sulfenyl amide bond between cys 215 and ser 216 |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 34940.07 |
Authors | Tanner, J.J.,Singh, H. (deposition date: 2011-06-27, release date: 2011-10-19, Last modification date: 2023-09-13) |
Primary citation | Zhou, H.,Singh, H.,Parsons, Z.D.,Lewis, S.M.,Bhattacharya, S.,Seiner, D.R.,Labutti, J.N.,Reilly, T.J.,Tanner, J.J.,Gates, K.S. The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133:15803-15805, 2011 Cited by PubMed: 21913686DOI: 10.1021/ja2077137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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