7O6G
| 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-176 | Descriptor: | 14-3-3 protein sigma, 4-[(3~{R})-3-oxidanylpiperidin-1-yl]carbonylbenzaldehyde, CALCIUM ION, ... | Authors: | Wolter, M, Ottmann, C. | Deposit date: | 2021-04-11 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
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3O7L
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5MUY
| Structure of a C-terminal domain of a reptarenavirus L protein with m7GTP | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, L protein | Authors: | Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. | Deposit date: | 2017-01-14 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
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5MV0
| Structure of an N-terminal domain of a reptarenavirus L protein | Descriptor: | L protein, PHOSPHATE ION | Authors: | Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. | Deposit date: | 2017-01-14 | Release date: | 2017-05-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
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4O1D
| Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors | Descriptor: | (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Coons, M, Brillantes, B, Wang, W. | Deposit date: | 2013-12-15 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.705 Å) | Cite: | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
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2DY5
| Crystal structure of rat heme oxygenase-1 in complex with heme and 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane | Descriptor: | 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE, CHLORIDE ION, Heme oxygenase 1, ... | Authors: | Sugishima, M, Takahashi, H, Fukuyama, K. | Deposit date: | 2006-09-06 | Release date: | 2007-05-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase Biochemistry, 46, 2007
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6E2H
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4MY2
| Crystal Structure of Norrin in fusion with Maltose Binding Protein | Descriptor: | Maltose-binding periplasmic protein, Norrin fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Ke, J, Jurecky, C, Chen, C, Gu, X, Parker, N, Williams, B.O, Melcher, K, Xu, H.E. | Deposit date: | 2013-09-27 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes Dev., 27, 2013
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3BBF
| Crystal structure of the NM23-H2 transcription factor complex with GDP | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Weichsel, A, Montfort, W.R. | Deposit date: | 2007-11-09 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Mol.Cancer Ther., 8, 2009
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3HFH
| Crystal structure of tandem FF domains | Descriptor: | Transcription elongation regulator 1 | Authors: | Lu, M, Yang, J, Ren, Z, Subir, S, Bedford, M.T, Jacobson, R.H, McMurray, J.S, Chen, X. | Deposit date: | 2009-05-11 | Release date: | 2009-08-18 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150. J.Mol.Biol., 393, 2009
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3BBB
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3BBC
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1R6R
| Solution Structure of Dengue Virus Capsid Protein Reveals a New Fold | Descriptor: | Genome polyprotein | Authors: | Ma, L, Jones, C.T, Groesch, T.D, Kuhn, R.J, Post, C.B. | Deposit date: | 2003-10-16 | Release date: | 2004-02-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of dengue virus capsid protein reveals another fold Proc.Natl.Acad.Sci.USA, 101, 2004
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1P7I
| CRYSTAL STRUCTURE OF ENGRAILED HOMEODOMAIN MUTANT K52A | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Segmentation polarity homeobox protein engrailed | Authors: | Stollar, E.J, Mayor, U, Lovell, S.C, Federici, L, Freund, S.M, Fersht, A.R, Luisi, B.F. | Deposit date: | 2003-05-02 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Engrailed Homeodomain Mutants: IMPLICATIONS FOR STABILITY AND DYNAMICS J.Biol.Chem., 278, 2003
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1P7J
| Crystal structure of engrailed homeodomain mutant K52E | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Segmentation polarity homeobox protein engrailed | Authors: | Stollar, E.J, Mayor, U, Lovell, S.C, Federici, L, Freund, S.M, Fersht, A.R, Luisi, B.F. | Deposit date: | 2003-05-02 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Engrailed Homeodomain Mutants: IMPLICATIONS FOR STABILITY AND DYNAMICS J.Biol.Chem., 278, 2003
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8K6Z
| NMR structure of human leptin | Descriptor: | Leptin | Authors: | Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z. | Deposit date: | 2023-07-26 | Release date: | 2024-02-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of human leptin reveals a conformational plasticity important for receptor recognition. Structure, 32, 2024
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1INR
| CYTOKINE SYNTHESIS | Descriptor: | INTERLEUKIN-10 | Authors: | Walter, M.R. | Deposit date: | 1995-07-31 | Release date: | 1996-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry, 34, 1995
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1R09
| HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837 | Descriptor: | 3-METHOXY-6-[4-(3-METHYLPHENYL)-1-PIPERAZINYL]PYRIDAZINE, DIMETHYL SULFOXIDE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), ... | Authors: | Chapman, M.S, Minor, I, Rossmann, M.G, Diana, G.D, Andries, K. | Deposit date: | 1990-05-04 | Release date: | 1991-10-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Human rhinovirus 14 complexed with antiviral compound R 61837. J.Mol.Biol., 217, 1991
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8OID
| Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | Deposit date: | 2023-03-22 | Release date: | 2023-08-09 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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8OI8
| Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | Deposit date: | 2023-03-22 | Release date: | 2023-08-16 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.28 Å) | Cite: | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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8P0D
| Human 14-3-3 sigma in complex with human MDM2 peptide | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. | Deposit date: | 2023-05-10 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
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6CP0
| SdcA in complex with the E2, UbcH5C | Descriptor: | SdcA, Ubiquitin-conjugating enzyme E2 D3 | Authors: | Wasilko, D.J, Huang, Q, Mao, Y. | Deposit date: | 2018-03-13 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Insights into the ubiquitin transfer cascade catalyzed by theLegionellaeffector SidC. Elife, 7, 2018
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1PFM
| PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 1-15 OF A 27-MODEL SET. | Descriptor: | PF4-M2 CHIMERA | Authors: | Mayo, K.H, Roongta, V, Ilyina, E, Milius, R, Barker, S, Quinlan, C, La Rosa, G, Daly, T.J. | Deposit date: | 1995-07-18 | Release date: | 1996-01-29 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Biochemistry, 34, 1995
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1PFN
| PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 16-27 OF A 27-MODEL SET. | Descriptor: | PF4-M2 CHIMERA | Authors: | Mayo, K.H, Roongta, V, Ilyina, E, Milius, R, Barker, S, Quinlan, C, La Rosa, G, Daly, T.J. | Deposit date: | 1995-07-18 | Release date: | 1996-01-29 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Biochemistry, 34, 1995
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2PK2
| Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat | Descriptor: | Cyclin-T1, Protein Tat | Authors: | Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. | Deposit date: | 2007-04-17 | Release date: | 2007-07-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat. J.Mol.Biol., 370, 2007
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