3BBF

Crystal structure of the NM23-H2 transcription factor complex with GDP

Summary for 3BBF

Entry DOI	10.2210/pdb3bbf/pdb
Related	1NUE 3BBB 3BBC
Descriptor	Nucleoside diphosphate kinase B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	transcription factor, cancer, kinase, nm23 gen, hexamer, activator, anti-oncogene, atp-binding, cell cycle, dna-binding, magnesium, metal-binding, nucleotide metabolism, nucleotide-binding, nucleus, phosphorylation, transcription regulation, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P22392
Total number of polymer chains	6
Total formula weight	106270.69
Authors	Weichsel, A.,Montfort, W.R. (deposition date: 2007-11-09, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	Dexheimer, T.S.,Carey, S.S.,Zuohe, S.,Gokhale, V.M.,Hu, X.,Murata, L.B.,Maes, E.M.,Weichsel, A.,Sun, D.,Meuillet, E.J.,Montfort, W.R.,Hurley, L.H. NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Mol.Cancer Ther., 8:1363-1377, 2009 Cited by PubMed: 19435876 DOI: 10.1158/1535-7163.MCT-08-1093 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation