3BBB

Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)

Summary for 3BBB

Related1NUE 3BBC 3BBF
DescriptorNucleoside diphosphate kinase B, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywordstranscription factor, cancer, nm23 gen, hexamer, activator, anti-oncogene, atp-binding, cell cycle, dna-binding, kinase, magnesium, metal-binding, nucleotide metabolism, nucleotide-binding, nucleus, phosphorylation, transcription regulation, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P22392
Total number of polymer chains6
Total molecular weight105208.48
Authors
Weichsel, A.,Montfort, W.R. (deposition date: 2007-11-09, release date: 2008-09-23, Last modification date: 2011-07-13)
Primary citation
Dexheimer, T.S.,Carey, S.S.,Zuohe, S.,Gokhale, V.M.,Hu, X.,Murata, L.B.,Maes, E.M.,Weichsel, A.,Sun, D.,Meuillet, E.J.,Montfort, W.R.,Hurley, L.H.
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1.
Mol.Cancer Ther., 8:1363-1377, 2009
PubMed: 19435876 (PDB entries with the same primary citation)
DOI: 10.1158/1535-7163.MCT-08-1093
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22640.7%1.9%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload