1INR

CYTOKINE SYNTHESIS

Summary for 1INR

• Entry DOI: 10.2210/pdb1inr/pdb
• Descriptor: INTERLEUKIN-10 (2 entities in total)
• Functional Keywords: cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P22301
• Total number of polymer chains: 1
• Total formula weight: 18672.45

Authors

Walter, M.R. (deposition date: 1995-07-31, release date: 1996-10-14, Last modification date: 2024-10-30)

Primary citation

Walter, M.R.,Nagabhushan, T.L.
Crystal structure of interleukin 10 reveals an interferon gamma-like fold.
Biochemistry, 34:12118-12125, 1995

PubMed Abstract: The crystal structure of recombinant human interleukin 10 (rhIL-10) has been determined by X-ray crystallography at 2.0 A resolution. Interleukin 10 is a dimer composed of identical polypeptide chains related by a 2-fold axis. The molecule is predominantly alpha-helical. The main-chain fold resembles that of interferon gamma (IFN-gamma) in which the structural integrity of each domain is dependent on the intertwining of helices from each peptide chain. Comparison of rhIL-10 and IFN-gamma reveals differences in helix lengths and orientations of the 2-fold related domains. Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold.

PubMed: 7547951
DOI: 10.1021/bi00038a004

Experimental method

X-RAY DIFFRACTION (2 Å)