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5Z12
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BU of 5z12 by Molmil
A structure of FXR/RXR
Descriptor: (9cis)-retinoic acid, 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor, ...
Authors:Lu, Y, Li, Y.
Deposit date:2017-12-23
Release date:2018-07-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
J. Biol. Chem., 293, 2018
5YXL
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BU of 5yxl by Molmil
A ligand M binding to FXR
Descriptor: 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2
Authors:Yi, L, Yong, L.
Deposit date:2017-12-05
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:A ligand M binding to FXR
To Be Published
5YXJ
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BU of 5yxj by Molmil
FXR ligand binding domain
Descriptor: 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2
Authors:Yi, L, Yong, L.
Deposit date:2017-12-05
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A ligand of drug binding to FXR
To Be Published
5YXD
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BU of 5yxd by Molmil
A ligand F binding to FXR
Descriptor: Bile acid receptor, Peptide from Nuclear receptor coactivator, ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
Authors:Yi, L, Yong, L.
Deposit date:2017-12-05
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A ligand F binding to FXR
To Be Published
5YXB
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BU of 5yxb by Molmil
A ligand binding to FXR
Descriptor: 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2
Authors:Yi, L, Yong, L.
Deposit date:2017-12-04
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A ligand binding to FXR
To Be Published
5YT2
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BU of 5yt2 by Molmil
Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol
Descriptor: (1R,2S,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol, Vitamin D3 receptor
Authors:Takimoto-Kamimura, M, Kakuda, S.
Deposit date:2017-11-16
Release date:2018-04-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.
Org. Biomol. Chem., 16, 2018
5YSY
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BU of 5ysy by Molmil
Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2R,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol
Descriptor: (1R,2R,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]e thenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol, Vitamin D3 receptor
Authors:Takimoto-Kamimura, M, Kakuda, S.
Deposit date:2017-11-16
Release date:2018-04-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.
Org. Biomol. Chem., 16, 2018
5YSO
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BU of 5yso by Molmil
Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434
Descriptor: 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma
Authors:Cho, S.J, Chin, J.W, Yoon, H.S, Jeon, Y.H, Bae, J.H, Song, J.Y.
Deposit date:2017-11-14
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERR gamma ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer.
Clin.Cancer Res., 25, 2019
5YP6
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BU of 5yp6 by Molmil
RORgamma (263-509) complexed with SRC2 and Compound 6
Descriptor: N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, SRC2
Authors:Gao, M, Cai, W.
Deposit date:2017-11-01
Release date:2018-02-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YP5
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BU of 5yp5 by Molmil
Crystal structure of RORgamma complexed with SRC2 and compound 5d
Descriptor: 2-[4-(ethylsulfonyl)phenyl]-N-{5-[2-(2-methylpropyl)benzoyl]-4-phenyl-1,3-thiazol-2-yl}acetamide, Nuclear receptor ROR-gamma, SRC2-2 peptide
Authors:Gao, M, Cai, W, Chunwa, C.
Deposit date:2017-11-01
Release date:2018-04-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YD6
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BU of 5yd6 by Molmil
Crystal structure of PG-bound Nurr1-LBD
Descriptor: (~{Z})-7-[(1~{R},5~{S})-2-oxidanylidene-5-[(~{E},3~{S})-3-oxidanyloct-1-enyl]cyclopent-3-en-1-yl]hept-5-enoic acid, MAGNESIUM ION, Nuclear receptor subfamily 4 group A member 2
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2017-09-11
Release date:2019-03-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure of Nurr1 bound to cyclopentenone prostaglandin A2 and its mechanism of action in ameliorating dopaminergic neurodegeneration in Drosophila
To Be Published
5YCP
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BU of 5ycp by Molmil
Human PPARgamma ligand binding domain complexed with Rosiglitazone
Descriptor: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Nuclear receptor coactivator 1, ...
Authors:Jang, J.Y, Han, B.W.
Deposit date:2017-09-07
Release date:2018-09-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPAR gamma.
Sci Rep, 8, 2018
5YCN
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BU of 5ycn by Molmil
Human PPARgamma ligand binding domain complexed with Lobeglitazone
Descriptor: (5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma
Authors:Jang, J.Y, Han, B.W.
Deposit date:2017-09-07
Release date:2018-09-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPAR gamma.
Sci Rep, 8, 2018
5Y7X
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BU of 5y7x by Molmil
Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist
Descriptor: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Kim, H.L, Chin, J.W, Cho, S.J, Song, J.Y, Yoon, H.S, Bae, J.H.
Deposit date:2017-08-18
Release date:2018-08-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Design, synthesis, and the X-ray co-crystal structure of Highly Potent, Selective, and Orally Bioavailable, Novel Peroxisome Proliferator-Activated Receptor delta Agonists
To Be Published
5Y49
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BU of 5y49 by Molmil
A moderator XD22 binding to bile acid receptor
Descriptor: Bile acid receptor, Peptide from Nuclear receptor coactivator 2, [(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl] 4-azanylbenzoate
Authors:Lu, Y, Li, Y.
Deposit date:2017-08-02
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A moderator XD22 binding to bile acid receptor
To Be Published
5Y44
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BU of 5y44 by Molmil
A novel moderator XD4 for bile acid receptor
Descriptor: Bile acid receptor, Peptide from Nuclear receptor coactivator 1, SULFATE ION, ...
Authors:Lu, Y, Li, Y.
Deposit date:2017-08-01
Release date:2019-02-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A novel moderator XD4 for bile acid receptor
To Be Published
5Y41
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BU of 5y41 by Molmil
Crystal Structure of LIGAND-BOUND NURR1-LBD
Descriptor: (13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sreekanth, R, Lescar, J, Yoon, H.S.
Deposit date:2017-07-31
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.
Nat.Chem.Biol., 2020
5Y2T
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BU of 5y2t by Molmil
Structure of PPARgamma ligand binding domain - lobeglitazone complex
Descriptor: (5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma
Authors:Im, Y.J, Lee, M.
Deposit date:2017-07-27
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of PPAR gamma complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs
Sci Rep, 7, 2017
5Y2O
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BU of 5y2o by Molmil
Structure of PPARgamma ligand binding domain-pioglitazone complex
Descriptor: (5S)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma
Authors:Im, Y.J, Lee, M.
Deposit date:2017-07-26
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structures of PPAR gamma complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs
Sci Rep, 7, 2017
5Y1J
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BU of 5y1j by Molmil
Crystal structure of human FXR in complex with a functional drug ligand
Descriptor: 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid, Bile acid receptor, Peptide from Nuclear receptor coactivator 2
Authors:Lu, Y, Li, Y.
Deposit date:2017-07-20
Release date:2018-10-31
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human FXR in complex with a functional drug liagnd
To Be Published
5XZH
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BU of 5xzh by Molmil
Vitamin D receptor with a synthetic ligand ADRO2
Descriptor: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
Authors:Otero, R, Numoto, N, Ikura, T, Yamada, S, Mourino, A, Makishima, M, Ito, N.
Deposit date:2017-07-12
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.
J. Med. Chem., 61, 2018
5XZF
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BU of 5xzf by Molmil
Vitamin D receptor with a synthetic ligand ADRO1
Descriptor: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6S)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, FORMIC ACID, Mediator of RNA polymerase II transcription subunit 1, ...
Authors:Otero, R, Numoto, N, Ikura, T, Yamada, S, Mourino, A, Makishima, M, Ito, N.
Deposit date:2017-07-12
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.
J. Med. Chem., 61, 2018
5XUQ
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BU of 5xuq by Molmil
Crystal structure of VDR-LBD complexed with an antagonist, 2-methylidene-19,26,27-trinor-22-(S)-butyl-1-hydroxy-25-oxo-25-(1H-pyrrol-2-yl)- vitamin D3
Descriptor: (4~{S})-4-[(1~{R})-1-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]ethyl]-1-(1~{H}-pyrrol-2-yl)octan-1-one, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
Authors:Kato, A, Itoh, T, Yamamoto, K.
Deposit date:2017-06-24
Release date:2018-06-27
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of Potent Vitamin D Receptor Antagonist
To Be Published
5XPP
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BU of 5xpp by Molmil
Crystal structure of VDR-LBD complexed with 25RS-(Hydroxyphenyl)-2-methylidene-19,26,27-trinor-1,25-dihydroxyvitamin D3
Descriptor: (1~{R},3~{R})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-1-[(2~{R},6~{R})-6-(4-hydroxyphenyl)-6-oxidanyl-hexan-2-yl]-7~{ a}-methyl-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
Authors:Kato, A, Itoh, T, Yamamoto, K.
Deposit date:2017-06-03
Release date:2018-06-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action
J. Med. Chem., 60, 2017
5XPO
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BU of 5xpo by Molmil
Crystal structure of VDR-LBD complexed with 25-(hydroxyphenyl)-2-methylidene-19,26,27-trinor-25-oxo-1-hydroxyvitamin D3
Descriptor: (5~{R})-5-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexyl idene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]-1-(4-hydroxyphenyl)hexan-1-one, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
Authors:Kato, A, Itoh, T, Yamamoto, K.
Deposit date:2017-06-03
Release date:2018-06-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action
J. Med. Chem., 60, 2017

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數據於2024-09-11公開中

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