5XZH

Vitamin D receptor with a synthetic ligand ADRO2

Summary for 5XZH

• Entry DOI: 10.2210/pdb5xzh/pdb
• Related: 5XZF
• Descriptor: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
• Functional Keywords: vitamin d receptor, vitamin d analogue, adamantan, transcription
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 32684.71

Authors

Otero, R.,Numoto, N.,Ikura, T.,Yamada, S.,Mourino, A.,Makishima, M.,Ito, N. (deposition date: 2017-07-12, release date: 2018-07-25, Last modification date: 2023-11-22)

• Primary citation: Otero, R.,Ishizawa, M.,Numoto, N.,Ikura, T.,Ito, N.,Tokiwa, H.,Mourino, A.,Makishima, M.,Yamada, S.; 25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.; J. Med. Chem., 61:6658-6673, 2018; PubMed: 29989817; DOI: 10.1021/acs.jmedchem.8b00427

Experimental method

X-RAY DIFFRACTION (2 Å)