5YSO

Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434

Summary for 5YSO

Entry DOI	10.2210/pdb5yso/pdb
Descriptor	Estrogen-related receptor gamma, 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol (3 entities in total)
Functional Keywords	sodium iodide symporter (nis), anaplastic thyroid cancer, estrogen-related receptor gamma, radioiodine therapy, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	82395.35
Authors	Cho, S.J.,Chin, J.W.,Yoon, H.S.,Jeon, Y.H.,Bae, J.H.,Song, J.Y. (deposition date: 2017-11-14, release date: 2018-12-26, Last modification date: 2023-11-22)
Primary citation	Singh, T.D.,Song, J.,Kim, J.,Chin, J.,Ji, H.D.,Lee, J.E.,Lee, S.B.,Yoon, H.,Yu, J.H.,Kim, S.K.,Yoon, G.S.,Hwang, H.,Lee, H.W.,Oh, J.M.,Lee, S.W.,Lee, J.,Choi, H.S.,Na, S.Y.,Choi, W.I.,Park, Y.J.,Song, Y.S.,Kim, Y.A.,Lee, I.K.,Cho, S.J.,Jeon, Y.H. A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERR gamma ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer. Clin.Cancer Res., 25:5069-5081, 2019 Cited by PubMed: 31010838 DOI: 10.1158/1078-0432.CCR-18-3007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.501 Å)

Structure validation