5YCN

Human PPARgamma ligand binding domain complexed with Lobeglitazone

Summary for 5YCN

• Entry DOI: 10.2210/pdb5ycn/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, ... (4 entities in total)
• Functional Keywords: ppargamma, agonist, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34666.07

Authors

Jang, J.Y.,Han, B.W. (deposition date: 2017-09-07, release date: 2018-09-12, Last modification date: 2023-11-22)

• Primary citation: Jang, J.Y.,Bae, H.,Lee, Y.J.,Choi, Y.I.,Kim, H.J.,Park, S.B.,Suh, S.W.,Kim, S.W.,Han, B.W.; Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPAR gamma.; Sci Rep, 8:31-31, 2018; PubMed: 29311579; DOI: 10.1038/s41598-017-18274-1

Experimental method

X-RAY DIFFRACTION (2.15 Å)