5Y7X

Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist

Summary for 5Y7X

• Entry DOI: 10.2210/pdb5y7x/pdb
• Descriptor: Peroxisome proliferator-activated receptor delta, 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: peroxisome proliferator-activated receptor, selenazole, diabetes, pi-sulfur interaction., protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68354.75

Authors

Kim, H.L.,Chin, J.W.,Cho, S.J.,Song, J.Y.,Yoon, H.S.,Bae, J.H. (deposition date: 2017-08-18, release date: 2018-08-01, Last modification date: 2023-11-22)

• Primary citation: Chin, J.W.,Cho, S.J.; Design, synthesis, and the X-ray co-crystal structure of Highly Potent, Selective, and Orally Bioavailable, Novel Peroxisome Proliferator-Activated Receptor delta Agonists; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.699 Å)