5Y7X

Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor delta	polymer	292	33319.6	2	UniProt (Q03181) Pfam (PF00104)	Homo sapiens (Human)	PPAR-delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta
2	C, H (A, B)	2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid	non-polymer		500.4	2	Chemie (8RR)
3	D (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
4	E, I (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	F (A)	S-1,2-PROPANEDIOL	non-polymer		76.1	1	Chemie (PGO)
6	G, J (A, B)	hexyl beta-D-glucopyranoside	non-polymer		264.3	2	Chemie (JZR)
7	K, L (A, B)	water	water		18.0	250	Chemie (HOH)

Sequence modifications

A, B: 171 - 441 (UniProt: Q03181)

PDB	External Database	Details
Met 150	-	expression tag
Gly 151	-	expression tag
Ser 152	-	expression tag
Ser 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag
His 156	-	expression tag
His 157	-	expression tag
His 158	-	expression tag
His 159	-	expression tag
Ser 160	-	expression tag
Ser 161	-	expression tag
Gly 162	-	expression tag
Leu 163	-	expression tag
Val 164	-	expression tag
Pro 165	-	expression tag
Arg 166	-	expression tag
Gly 167	-	expression tag
Ser 168	-	expression tag
His 169	-	expression tag
Met 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66639.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1715.5
All*	Total formula weight	68354.7

*Water molecules are not included.