PDB: 1374 resultsInfo pagesStatus searchChemie searchBIRD

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5CLQ	Ran Y39A in complex with GPPNHP and RanBD1 Descriptor: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... Authors: Vetter, I.R, Brucker, S. Deposit date: 2015-07-16 Release date: 2015-09-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
5CM8	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
5CM9	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
5DH9	Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DHA	Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIS	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. Deposit date: 2015-09-01 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep, 13, 2015
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex Descriptor: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... Authors: Aksu, M, Trakhanov, S, Gorlich, D. Deposit date: 2015-09-07 Release date: 2016-06-22 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016
5E95	Crystal Structure of Mb(NS1)/H-Ras Complex Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Eguchi, R.R, Sha, F, Gupta, A, Koide, A, Koide, S. Deposit date: 2015-10-14 Release date: 2016-11-02 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.402 Å) Cite: Inhibition of RAS function through targeting an allosteric regulatory site. Nat. Chem. Biol., 13, 2017
5EUQ	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Burke, J.E, Fowler, M.L. Deposit date: 2015-11-19 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta. J.Med.Chem., 59, 2016
5EZ5	Crystal structure of active Rab11A (S20V) in complex with GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-11A Authors: Shin, Y.-C, Yoon, J.H, Park, H.H. Deposit date: 2015-11-26 Release date: 2016-12-07 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of active Rab11A (S20V) in complex with GTP To Be Published
5EZ6	Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA Authors: Yan, Z, Ma, S, Zhang, Y, Ma, L, Wang, F, Li, J, Miao, L. Deposit date: 2015-11-26 Release date: 2016-12-07 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA To Be Published
5F2E	Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C Descriptor: 1-[3-[4-[2-[[4-chloranyl-5-(1-methylcyclopropyl)-2-oxidanyl-phenyl]amino]ethanoyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one, GLYCEROL, GLYCINE, ... Authors: Patricelli, M.P, Janes, M.R, Li, L.-S, Hansen, R, Peters, U, Kessler, L.V, Chen, Y, Kucharski, J.M, Feng, J, Ely, T, Chen, J.H, Firdaus, S.J, Babbar, A, Ren, P, Liu, Y. Deposit date: 2015-12-01 Release date: 2016-01-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6, 2016
5FBL	PI4KB in complex with Rab11 and the MI356 Inhibitor Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. Deposit date: 2015-12-14 Release date: 2016-12-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.372 Å) Cite: PI4KB in complex with Rab11 and the MI356 Inhibitor To Be Published
5FBQ	PI4KB in complex with Rab11 and the MI358 Inhibitor Descriptor: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. Deposit date: 2015-12-14 Release date: 2016-12-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.789 Å) Cite: PI4KB in complex with Rab11 and the MI358 Inhibitor To Be Published
5FBR	PI4KB in complex with Rab11 and the MI359 Inhibitor Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. Deposit date: 2015-12-14 Release date: 2016-12-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.28 Å) Cite: PI4KB in complex with Rab11 and the MI359 Inhibitor To Be Published
5FBV	PI4KB in complex with Rab11 and the MI364 Inhibitor Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. Deposit date: 2015-12-14 Release date: 2016-12-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.285 Å) Cite: PI4KB in complex with Rab11 and the MI364 Inhibitor To Be Published
5FBW	PI4KB in complex with Rab11 and the MI369 Inhibitor Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... Authors: Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. Deposit date: 2015-12-14 Release date: 2016-12-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.487 Å) Cite: PI4KB in complex with Rab11 and the MI369 Inhibitor To Be Published
5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 Authors: Cash, J.N, Tesmer, J.J.G. Deposit date: 2015-12-22 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.282 Å) Cite: Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Authors: Cash, J.N, Tesmer, J.J.G. Deposit date: 2015-12-22 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.203 Å) Cite: Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
5FR1	Double acetylated RhoGDI-alpha in complex with RhoA-GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RHO GDP-DISSOCIATION INHIBITOR 1, ... Authors: Kuhlmann, N, Wroblowski, S, Lammers, M. Deposit date: 2015-12-15 Release date: 2016-01-13 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Rhogdi Alpha Acetylation at K127 and K141 Affects Binding Towards Non-Prenylated Rhoa. Biochemistry, 55, 2016
5FR2	Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 Descriptor: FARNESYL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Kuhlmann, N, Wroblowski, S, Knyphausen, P, de Boor, S, Brenig, J, Zienert, A.Y, Meyer-Teschendorf, K, Praefcke, G.J.K, Nolte, H, Krueger, M, Schacherl, M, Baumann, U, James, L.C, Chin, J.W, Lammers, M. Deposit date: 2015-12-15 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation. J.Biol.Chem., 291, 2016
5HPY	Crystal Structure of RhoA.GDP.MgF3-in complex with human Myosin 9b RhoGAP domain Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRIFLUOROMAGNESATE, ... Authors: Yi, F.S, Ren, J.Q, Feng, W. Deposit date: 2016-01-21 Release date: 2016-07-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism J.Mol.Biol., 428, 2016

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