5F2E

Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C

Summary for 5F2E

Entry DOI	10.2210/pdb5f2e/pdb
Descriptor	GTPase KRas, MAGNESIUM ION, GLYCEROL, ... (7 entities in total)
Functional Keywords	small gtpase domain, covalent inhibitor bound, switch ii pocket, gdp bound, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains	1
Total formula weight	20512.49
Authors	Patricelli, M.P.,Janes, M.R.,Li, L.-S.,Hansen, R.,Peters, U.,Kessler, L.V.,Chen, Y.,Kucharski, J.M.,Feng, J.,Ely, T.,Chen, J.H.,Firdaus, S.J.,Babbar, A.,Ren, P.,Liu, Y. (deposition date: 2015-12-01, release date: 2016-01-13, Last modification date: 2023-09-27)
Primary citation	Patricelli, M.P.,Janes, M.R.,Li, L.S.,Hansen, R.,Peters, U.,Kessler, L.V.,Chen, Y.,Kucharski, J.M.,Feng, J.,Ely, T.,Chen, J.H.,Firdaus, S.J.,Babbar, A.,Ren, P.,Liu, Y. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6:316-329, 2016 Cited by PubMed: 26739882 DOI: 10.1158/2159-8290.CD-15-1105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation