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5WUE	Structural basis for conductance through TRIC cation channels Descriptor: SULFATE ION, Uncharacterized protein Authors: Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) Deposit date: 2016-12-17 Release date: 2017-06-21 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
5YKG	Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A) Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... Authors: Chen, L, Wu, J.X. Deposit date: 2017-10-14 Release date: 2018-04-18 Last modified: 2018-06-13 Method: ELECTRON MICROSCOPY (4.57 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5Y2G	Structure of MBP tagged GBS CAMP Descriptor: Maltose-binding periplasmic protein,Protein B, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Jin, T, Li, Y. Deposit date: 2017-07-25 Release date: 2019-02-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure determination of the CAMP factor of Streptococcus agalactiae with the aid of an MBP tag and insights into membrane-surface attachment. Acta Crystallogr D Struct Biol, 75, 2019
5Y5V	Crystal structure of a novel Pyrethroid Hydrolase PytH (S78A) Descriptor: Pyrethroid hydrolase, SULFATE ION Authors: Xu, D.Q, Ran, T.T, He, J, Wang, W.W. Deposit date: 2017-08-09 Release date: 2018-08-15 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2 To Be Published
5YAC	Crystal structure of WT Trm5b from Pyrococcus abyssi Descriptor: tRNA (guanine(37)-N1)-methyltransferase Trm5b Authors: Xie, W, Wu, J. Deposit date: 2017-08-31 Release date: 2017-09-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.3 Å) Cite: The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b Biochem. Biophys. Res. Commun., 493, 2017
5YE5	structure of endo-lysosomal TRPML1 channel inserting into nanodisc Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, mammalian endo-lysosomal TRPML1 channel Authors: Yang, M, Gao, N. Deposit date: 2017-09-15 Release date: 2017-11-15 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism Protein Cell, 8, 2017
5YDZ	structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 1 Descriptor: mammalian endo-lysosomal TRPML1 channel Authors: Yang, M, Gao, N. Deposit date: 2017-09-15 Release date: 2017-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism Protein Cell, 8, 2017
5YKE	Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A) Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11 Authors: Chen, L, Wu, J.X. Deposit date: 2017-10-14 Release date: 2018-04-18 Last modified: 2018-06-13 Method: ELECTRON MICROSCOPY (4.11 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5WUK	Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound Descriptor: GLYCEROL, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Chen, Z. Deposit date: 2016-12-19 Release date: 2017-05-03 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522, 2017
5WO4	JAK1 complexed with compound 28 Descriptor: 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1 Authors: Lesburg, C.A, Patel, S.B. Deposit date: 2017-08-01 Release date: 2017-12-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.84 Å) Cite: The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J. Med. Chem., 60, 2017
5WPT	Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION Authors: Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. Deposit date: 2017-08-07 Release date: 2017-10-18 Last modified: 2023-04-05 Method: ELECTRON MICROSCOPY (3.75 Å) Cite: Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
5YGS	Human TNFRSF25 death domain Descriptor: Human TNRSF25 death domain, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Yin, X, Jin, T. Deposit date: 2017-09-26 Release date: 2018-10-03 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.691 Å) Cite: Crystal structure and activation mechanism of DR3 death domain. Febs J., 286, 2019
5YI7	Crystal structure of drosophila Numb PTB domain and Pon peptide complex Descriptor: GLYCEROL, Pon peptide from Partner of numb, Protein numb Authors: Shan, Z, Wen, W. Deposit date: 2017-10-03 Release date: 2018-04-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat Commun, 9, 2018
5WT3	Pyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNA Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, RNA (73-MER), tRNA (guanine(37)-N1)-methyltransferase Trm5a Authors: Xie, W, Wang, C, Jia, Q. Deposit date: 2016-12-09 Release date: 2017-12-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.204 Å) Cite: Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Sci Adv, 3, 2017
5YWC	Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A) Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... Authors: Chen, L, Wu, J.X. Deposit date: 2017-11-29 Release date: 2018-05-02 Last modified: 2018-06-13 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YW9	Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A) Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER Authors: Chen, L, Wu, J.X. Deposit date: 2017-11-29 Release date: 2018-05-02 Last modified: 2018-06-13 Method: ELECTRON MICROSCOPY (5 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YWB	Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A) Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... Authors: Chen, L, Wu, J.X. Deposit date: 2017-11-29 Release date: 2018-05-30 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5ZFM	Ketoreductase LbCR mutant - M6 Descriptor: 3-oxoacyl-acyl carrier protein reductase Authors: Gong, X.M, Zheng, G.W, Xu, J.H. Deposit date: 2018-03-06 Release date: 2019-01-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor Acs Catalysis, 9, 2019
5YW8	Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A) Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER Authors: Chen, L, Wu, J.X. Deposit date: 2017-11-29 Release date: 2018-05-02 Last modified: 2018-06-13 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5ZGU	Crystal structure of NDM-1 at pH7.0 (HEPES) with 2 molecules per asymmetric unit Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, HYDROXIDE ION, ... Authors: Zhang, H, Hao, Q. Deposit date: 2018-03-10 Release date: 2018-08-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
5ZI0	Ketoreductase LbCR mutant - M8 Descriptor: 3-oxoacyl-acyl carrier protein reductase Authors: Gong, X.M, Zheng, G.W, Xu, J.H. Deposit date: 2018-03-14 Release date: 2019-01-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.302 Å) Cite: Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor Acs Catalysis, 9, 2019
5Z96	Structure of the mouse TRPC4 ion channel Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... Authors: Duan, J, Li, Z, Li, J, Zhang, J. Deposit date: 2018-02-02 Release date: 2018-04-18 Last modified: 2018-08-29 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Structure of the mouse TRPC4 ion channel. Nat Commun, 9, 2018
5WPV	Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION Authors: Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. Deposit date: 2017-08-07 Release date: 2017-10-18 Last modified: 2023-04-05 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
5WUC	Structural basis for conductance through TRIC cation channels Descriptor: SODIUM ION, Uncharacterized protein Authors: Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) Deposit date: 2016-12-17 Release date: 2017-07-12 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
5YWD	Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A) Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, MAGNESIUM ION Authors: Chen, L, Wu, J.X. Deposit date: 2017-11-29 Release date: 2018-05-02 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

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