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7KTT	Cryogenic electron microscopy model of full-length human metavinculin Descriptor: metavinculin Authors: Izard, T, Rangarajan, E.S. Deposit date: 2020-11-24 Release date: 2021-01-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.17 Å) Cite: The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain. Int J Mol Sci, 22, 2021
7KTW	Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 2 Descriptor: metavinculin Authors: Izard, T, Rangarajan, E.S. Deposit date: 2020-11-24 Release date: 2021-01-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.27 Å) Cite: The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain. Int J Mol Sci, 22, 2021
4E17	Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin Descriptor: Catenin alpha-1, Vinculin Authors: Choi, H.-J, Pokutta, S, Cadwell, G.W, Bankston, L.A, Liddington, R.C, Weis, W.I. Deposit date: 2012-03-05 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Conformational plasticity of alpha-catenin revealed by binding interactions with vinculin To be Published
4DJ9	Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099) Descriptor: Talin-1, Vinculin Authors: Yogesha, S.D, Rangarajan, E.S, Vonrhein, C, Bricogne, G, Izard, T. Deposit date: 2012-02-01 Release date: 2012-02-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin. Protein Sci., 21, 2012
4E18	Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin Descriptor: Catenin alpha-1, Vinculin Authors: Choi, H.-J, Pokutta, S, Cadwell, G.W, Bankston, L.A, Liddington, R.C, Weis, W.I. Deposit date: 2012-03-05 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.403 Å) Cite: Conformational plasticity of alpha-catenin revealed by binding interactions with vinculin To be Published
7KTU	Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 1 Descriptor: metavinculin Authors: Izard, T, Rangarajan, E.S. Deposit date: 2020-11-24 Release date: 2021-01-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.15 Å) Cite: The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain. Int J Mol Sci, 22, 2021
4EHP	Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382) Descriptor: ACETATE ION, Catenin alpha-1, Vinculin Authors: Izard, T, Rangarajan, E.S. Deposit date: 2012-04-03 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.66 Å) Cite: alpha-Catenin unfurls upon binding to vinculin J.Biol.Chem., 287, 2012
7KTV	Cryogenic electron microscopy model of full-length human metavinculin H1' kinked conformation Descriptor: metavinculin Authors: Izard, T, Rangarajan, E.S. Deposit date: 2020-11-24 Release date: 2021-01-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain. Int J Mol Sci, 22, 2021
1XWJ	Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969) Descriptor: Talin, Vinculin Authors: Gingras, A.R, Papagrigoriou, E, Barsukov, I.L, Critchley, D.R, Emsley, J. Deposit date: 2004-11-01 Release date: 2005-10-11 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod Biochemistry, 45, 2006
1YDI	Human Vinculin Head Domain (VH1, 1-258) in Complex with Human Alpha-Actinin's Vinculin-Binding Site (Residues 731-760) Descriptor: Alpha-actinin 4, vinculin isoform VCL Authors: Izard, T. Deposit date: 2004-12-23 Release date: 2005-07-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Dynamics of {alpha}-Actinin-Vinculin Interactions. Mol.Cell.Biol., 14, 2005
1ZW3	Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-1652 Descriptor: Talin 1, Vinculin Authors: Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. Deposit date: 2005-06-03 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod J.Biol.Chem., 280, 2005
1ZVZ	Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-844 Descriptor: Talin 1, Vinculin Authors: Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. Deposit date: 2005-06-03 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod J.Biol.Chem., 280, 2005
1ZW2	Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-2369 Descriptor: Vinculin, talin Authors: Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. Deposit date: 2005-06-03 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod J.Biol.Chem., 280, 2005
1T01	Vinculin complexed with the VBS1 helix from talin Descriptor: Talin 1, unnamed protein product Authors: Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. Deposit date: 2004-04-07 Release date: 2004-08-24 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle Embo J., 23, 2004
1TR2	Crystal structure of human full-length vinculin (residues 1-1066) Descriptor: VINCULIN ISOFORM 1 Authors: Borgon, R.A, Vonrhein, C, Bricogne, G, Bois, P.R, Izard, T. Deposit date: 2004-06-19 Release date: 2005-11-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of Human Vinculin Structure, 12, 2004
5L0C	Human metavinculin (residues 959-1134) in complex with PIP2 Descriptor: PHOSPHATE ION, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
5L0F	Human metavinculin quadruple mutant (residues 959-1134) Descriptor: GLYCEROL, Vinculin Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.76 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
1RKC	Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969) Descriptor: Talin, Vinculin Authors: Izard, T, Evans, G, Borgon, R.A, Rush, C.L, Bricogne, G, Bois, P.R. Deposit date: 2003-11-21 Release date: 2004-01-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Vinculin activation by talin through helical bundle conversion Nature, 427, 2004
5L0G	Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2 Descriptor: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
5L0D	Human Metavinculin(residues 959-1130) in complex with PIP2 Descriptor: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
5L0H	Human metavinculin MVt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with PIP2 Descriptor: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Vinculin, ... Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
5L0I	Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134) Descriptor: GLYCEROL, SODIUM ION, Vinculin Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
5L0J	Human vinculin R903Q, D907R, R910T mutant(residues 891-1066) Descriptor: Vinculin Authors: Chinthalapudi, K, Izard, T. Deposit date: 2016-07-27 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4 Å) Cite: Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
1U6H	Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879) Descriptor: Talin, Vinculin Authors: Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. Deposit date: 2004-07-30 Release date: 2005-01-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.38 Å) Cite: A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head. Structure, 13, 2005
1RKE	Human vinculin head (1-258) in complex with human vinculin tail (879-1066) Descriptor: VCL protein, Vinculin Authors: Izard, T, Evans, G, Borgon, R.A, Rush, C.L, Bricogne, G, Bois, P.R. Deposit date: 2003-11-21 Release date: 2004-01-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Vinculin activation by talin through helical bundle conversion Nature, 427, 2004

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