3PPY
| Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3QA3
| Crystal Structure of A-domain in complex with antibody | Descriptor: | 1,2-ETHANEDIOL, Antibody Heavy chain, Antibody Light chain, ... | Authors: | Mahalingam, B, Xiong, J.P, Arnaout, M.A. | Deposit date: | 2011-01-10 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design. J.Immunol., 187, 2011
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5HGJ
| Structure of integrin alpha1beta1 and alpha2beta1 I-domains explain differential calcium-mediated ligand recognition | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Brown, K.L, Banerjee, S, Feigley, A, Abe, H, Blackwell, T, Zent, R, Pozzi, A, Hudson, B.H. | Deposit date: | 2016-01-08 | Release date: | 2017-04-12 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | Salt-bridge modulates differential calcium-mediated ligand binding to integrin alpha 1- and alpha 2-I domains. Sci Rep, 8, 2018
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5HJ2
| Integrin alpha2beta1 I-domain | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Brown, K.L, Banerjee, S. | Deposit date: | 2016-01-12 | Release date: | 2017-04-12 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.153 Å) | Cite: | Salt-bridge modulates differential calcium-mediated ligand binding to integrin alpha 1- and alpha 2-I domains. Sci Rep, 8, 2018
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3RAG
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3BQN
| LFA-1 I domain bound to inhibitors | Descriptor: | 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine, Integrin alpha-L | Authors: | Silvian, L.F. | Deposit date: | 2007-12-20 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3BQM
| LFA-1 I domain bound to inhibitors | Descriptor: | 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline, Integrin alpha-L | Authors: | Silvian, L.F. | Deposit date: | 2007-12-20 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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4HQK
| Crystal structure of Plasmodium falciparum TRAP, P4212 form | Descriptor: | SULFATE ION, Thrombospondin-related anonymous protein, TRAP | Authors: | Song, G, Koksal, A.C, Lu, C, Springer, T.A. | Deposit date: | 2012-10-25 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.249 Å) | Cite: | Shape change in the receptor for gliding motility in Plasmodium sporozoites. Proc.Natl.Acad.Sci.USA, 109, 2012
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4IHK
| Crystal structure of the Collagen VI alpha3 N5 domain R1061Q | Descriptor: | Collagen alpha3(VI) | Authors: | Mikolajek, H, Becker, A.K.A, Paulsson, M, Wagener, R, Werner, J.M. | Deposit date: | 2012-12-19 | Release date: | 2013-12-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein Structure, 22, 2014
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4IGI
| Crystal structure of the Collagen VI alpha3 N5 domain | Descriptor: | Collagen alpha3(VI) | Authors: | Mikolajek, H, Becker, A.K.A, Paulsson, M, Wagener, R, Werner, J.M. | Deposit date: | 2012-12-17 | Release date: | 2013-12-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein Structure, 22, 2014
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4IXD
| X-ray structure of lfa-1 i-domain in complex with ibe-667 at 1.8a resolution | Descriptor: | 4-(3-{4-[(3-aminopropyl)carbamoyl]phenyl}-1H-indazol-1-yl)-N-methylbenzamide, Integrin alpha-L, MAGNESIUM ION | Authors: | Kallen, J. | Deposit date: | 2013-01-25 | Release date: | 2014-01-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification and x-ray structure based investigation of an ICAM-1 binding enhancing small molecule activator of LFA-1 To be Published, 2013
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4JDU
| The crystal structure of an aerotolerance-related membrane protein from Bacteroides fragilis NCTC 9343 with multiple mutations to serines. | Descriptor: | Aerotolerance-related membrane protein, CALCIUM ION, FORMIC ACID | Authors: | Fan, Y, Tan, K, Bigelow, L, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-02-25 | Release date: | 2013-03-27 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | The crystal structure of an aerotolerance-related membrane protein from Bacteroides fragilis NCTC 9343 with multiple mutations to serines. To be Published
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3E2M
| LFA-1 I domain bound to inhibitors | Descriptor: | Integrin alpha-L, cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid | Authors: | Silvian, L.F. | Deposit date: | 2008-08-05 | Release date: | 2008-08-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3EOB
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3EOA
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3F78
| Crystal structure of wild type LFA1 I domain complexed with isoflurane | Descriptor: | 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, Integrin alpha-L, ... | Authors: | Zhang, H, Wang, J.-H. | Deposit date: | 2008-11-07 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23, 2009
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3F74
| Crystal structure of wild type LFA1 I domain | Descriptor: | GLYCEROL, Integrin alpha-L, MAGNESIUM ION | Authors: | Zhang, H, Wang, J.-H. | Deposit date: | 2008-11-07 | Release date: | 2009-06-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23, 2009
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3GXB
| Crystal structure of VWF A2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | Authors: | Zhou, Y.F, Springer, T.A. | Deposit date: | 2009-04-02 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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4C29
| Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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4CN9
| structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus with zinc occupied MIDAS motif | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, PROXIMAL THREAD MATRIX PROTEIN 1, ... | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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4CNB
| Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus - Crystal form 2 | Descriptor: | 1,2-ETHANEDIOL, PROXIMAL THREAD MATRIX PROTEIN 1, SULFATE ION | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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4CN8
| Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus | Descriptor: | 1,2-ETHANEDIOL, PROXIMAL THREAD MATRIX PROTEIN 1, SULFATE ION | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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1XDG
| X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution | Descriptor: | (1S,3R,8AS)-8-(2-{(4S,6S)-3-(4-HYDROXY-3-METHOXYBENZYL)-4-[2-(METHYLAMINO)-2-OXOETHYL]-2-OXO-1,3-OXAZINAN-6-YL}ETHYL)-3 ,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL (2R)-2-METHYLBUTANOATE, Integrin alpha-L, MAGNESIUM ION | Authors: | Weitz-Schmidt, G, Welzenbach, K, Dawson, J, Kallen, J. | Deposit date: | 2004-09-06 | Release date: | 2004-09-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo J.Biol.Chem., 279, 2004
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4DMU
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1XDD
| X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution | Descriptor: | 8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE, Integrin alpha-L, MAGNESIUM ION | Authors: | Weitz-Schmidt, G, Welzenbach, K, Dawson, J, Kallen, J. | Deposit date: | 2004-09-06 | Release date: | 2004-09-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo J.Biol.Chem., 279, 2004
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